Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
Sign Up to like & getrecommendations! Published in 2023 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.3c00047
Abstract: Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent enzymes. Oxythiamine has been used to… read more here.
Keywords: thiamine; thiamine diphosphate; dependent enzymes; thiamine utilization ... See more keywords
Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C-C Bond.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06546
Abstract: Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX), produced by the soil-dwelling bacterium Saccharothrix sp. ST-888, exhibits herbicidal activity. In this study, we propose a… read more here.
Keywords: thiamine diphosphate; dependent enzymes; phosphonate phosphonothrixin; complete biosynthetic ... See more keywords
Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis
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DOI: 10.1159/000480651
Abstract: Aim: (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form of vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish the impact of a… read more here.
Keywords: tdp; end stage; dialysis related; blood ... See more keywords