Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
Sign Up to like & getrecommendations! Published in 2023 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.3c00047
Abstract: Thiamine is metabolized into the coenzyme thiamine diphosphate (ThDP). Interrupting thiamine utilization leads to disease states. Oxythiamine, a thiamine analogue, is metabolized into oxythiamine diphosphate (OxThDP), which inhibits ThDP-dependent enzymes. Oxythiamine has been used to… read more here.
Keywords: thiamine; thiamine diphosphate; dependent enzymes; thiamine utilization ... See more keywords
Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C-C Bond.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06546
Abstract: Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX), produced by the soil-dwelling bacterium Saccharothrix sp. ST-888, exhibits herbicidal activity. In this study, we propose a… read more here.
Keywords: thiamine diphosphate; dependent enzymes; phosphonate phosphonothrixin; complete biosynthetic ... See more keywords
Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis
Sign Up to like & getrecommendations! Published in 2017 at "Blood Purification"
DOI: 10.1159/000480651
Abstract: Aim: (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form of vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish the impact of a… read more here.
Keywords: tdp; end stage; dialysis related; blood ... See more keywords
Covalent Docking to the Active Sites of Thiamine Diphosphate-Dependent Enzymes
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30224427
Abstract: The search for novel low-molecular regulators using molecular docking continues to be crucial for addressing challenges in modern biomedical science. However, the current literature lacks examples of modeling covalent interactions between the ligands being docked… read more here.
Keywords: docking active; active sites; dependent enzymes; covalent docking ... See more keywords