From classical to supramolecular dynamic stereochemistry: Double crystallization-induced diastereomerization of thiazine sulfonamide.
Sign Up to like & getrecommendations! Published in 2021 at "Chirality"
DOI: 10.1002/chir.23316
Abstract: The interrelation between the configurational lability of nitrogen and sulfur atoms within the -NH-SO2 group of some thiazine sulfonamides is discussed. We have found that the compounds of the above series can crystallize as various… read more here.
Keywords: induced diastereomerization; double crystallization; crystallization induced; thiazine ... See more keywords
Evaluation of angularly condensed diquinothiazines as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.04.005
Abstract: We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2'-dichloro-3,3'-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines. The pentacyclic diquinothiazine ring systems were identified as diquino[3,2-b;3',4'-e][1,4]thiazine, diquino[3,2-b;5',6'-e][1,4]thiazine,… read more here.
Keywords: diquino thiazine; evaluation angularly; thiazine; cancer ... See more keywords
Regioselective synthesis of new 5H,10H-dipyrimido[2,1-b:4′,5′-d][1,3]thiazine: a combined experimental and computational study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Sulfur Chemistry"
DOI: 10.1080/17415993.2019.1576685
Abstract: ABSTRACT Several derivatives of the novel tricyclic system ‘dipyrimido[2,1-b:4′,5′-d][1,3]thiazine’ were synthesized via inter- and intramolecular heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine and 6-amino-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile in short reaction times under mild conditions. An x-ray analysis together with computational calculations was… read more here.
Keywords: synthesis new; thiazine; dipyrimido thiazine; 10h dipyrimido ... See more keywords
Carbene-Catalyzed Atroposelective Annulation for Quick Access to Axially Chiral Thiazine Derivatives
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DOI: 10.3390/molecules28104052
Abstract: An N-heterocyclic carbene (NHC)-catalyzed atroposelective annulation reaction is disclosed for quick and efficient access to thiazine derivatives. A series of axially chiral thiazine derivatives bearing various substituents and substitution patterns were produced in moderate to… read more here.
Keywords: atroposelective annulation; thiazine derivatives; chiral thiazine; thiazine ... See more keywords