LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "thiazol one" as a keyword



Photo by nci from unsplash

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights

Sign Up to like & get
recommendations! Published in 2022 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s356988

Abstract: Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR kinase inhibitors are of increasing interest as promising targeted antitumor therapeutic agents. Methods Different… read more here.

Keywords: molecular docking; cell; thiazolyl pyrazolines; thiazol one ... See more keywords
Photo by julienlphoto from unsplash

Novel 2-(Adamantan-1-ylamino)Thiazol-4(5H)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies

Sign Up to like & get
recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22168609

Abstract: A common mechanism in which glucocorticoids participate is suggested in the pathogenesis of such metabolic diseases as obesity, metabolic syndrome, or Cushing’s syndrome. The enzyme involved in the control of the availability of cortisol, the… read more here.

Keywords: ylamino thiazol; thiazol one; novel adamantan; adamantan ylamino ... See more keywords
Photo by julienlphoto from unsplash

Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24087252

Abstract: In this study, a series of nine new 2-(cyclopentylamino)thiazol-4(5H)-one derivatives were synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitory activities were tested. Anticancer activity has been assessed using the MTS (MTS: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay… read more here.

Keywords: cyclopentylamino thiazol; inhibitory; thiazol one; one derivatives ... See more keywords