A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22022
Abstract: In an attempt to identify potent antitumor agents for the fight against non‐small cell lung cancer, new thiazolyl hydrazones (2a–n) were synthesized and examined for their in vitro cytotoxic effects on A549 human lung adenocarcinoma… read more here.
Keywords: cell; non small; ic50; lung ... See more keywords
Highly refractive thiazole-containing polyimides: a structural property comparison
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DOI: 10.1007/s10965-018-1495-5
Abstract: Highly refractive, thermally stable, and solution processable polyimides (PIs) were synthesized by the introduction of thiazole units, thioether linkages, and phenyl or nitrophenyl groups into the polymer backbones. These PIs were prepared via the polycondensation… read more here.
Keywords: refractive thiazole; thiazole; highly refractive; phenyl nitrophenyl ... See more keywords
Design, synthesis, and biological evaluation of thiazole bioisosteres of goniofufurone through in vitro antiproliferative activity and in vivo toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105691
Abstract: The synthesis of several new goniofufurone bioisosteres was achieved in which the phenyl residue was replaced by a thiazole ring. The key steps of the synthesis included the initial condensation of cyanohydrin benzoates with cysteine… read more here.
Keywords: evaluation; toxicity; antiproliferative activity; synthesis ... See more keywords
Benzo[d]thiazole-2-carbanilides as new anti-TB chemotypes: Design, synthesis, biological evaluation, and structure-activity relationship.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.049
Abstract: Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism urges for new anti-TB drugs. Seventy-two benzo[d]thiazole-2-carbanilides have been synthesized through… read more here.
Keywords: thiazole; new anti; benzo thiazole; structure activity ... See more keywords
1,3-Thiazole on Cu(100) and O/Cu(100): Adsorption and Reaction Pathways
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DOI: 10.1021/acs.jpcc.0c04041
Abstract: 1,3-Thiazole is found to be nearly perpendicularly adsorbed on Cu(100), with the N atom attaching to an atop site and an adsorption energy of ∼19.5 kcal·mol–1. The N–C–S moiety of the adsorbed 1,3-thiazole has a… read more here.
Keywords: 100 100; adsorption; thiazole; thiazole 100 ... See more keywords
Thiazole Containing Heterocycles with Antimalarial Activity.
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DOI: 10.2174/1570163814666170725114159
Abstract: BACKGROUND Heterocyclic compounds are the main class of medicinally important compounds. Many heterocyclic compounds bearing a five-membered ring in their structure have a good spectrum of biological activities. Thiazole is an important class of five-membered… read more here.
Keywords: thiazole; heterocyclic compounds; drug; antimalarial activity ... See more keywords