Exploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103988
Abstract: Several novel series of hydroxamic acids bearing 2-benzamidooxazole/thiazole (5a-g, 6a-g) or 2-phenylsulfonamidothiazole (8a-c) were designed and synthesized. The compounds were obtained straightforwards via a two step pathway, starting from commercially available ethyl 2-aminooxazole-4-carboxylate or ethyl… read more here.
Keywords: based hydroxamic; inhibitors antitumor; hydroxamic acids; thiazole based ... See more keywords
Synthesis and multicolor, photophysical, thermal, and conductivity properties of poly(imine)s
Sign Up to like & getrecommendations! Published in 2021 at "Journal of The Taiwan Institute of Chemical Engineers"
DOI: 10.1016/j.jtice.2021.05.010
Abstract: Abstract Background Thiazole-based conjugated have been attracted much attention due to their desirable photophysical properties. Based on this, we aimed to prepare thiazole-based poly(imine)s with tunable multicolor emission behavior in the present paper. Methods Thiazole-based… read more here.
Keywords: thiazole based; poly imine; multicolor; behavior ... See more keywords
Tailoring the Physicochemical Properties of Antimicrobial Peptides onto Thiazole-based γ-Peptide Foldamer.
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DOI: 10.1021/acs.jmedchem.0c00077
Abstract: Antimicrobial peptides (AMPs) are amphipathic molecules displaying broad-spectrum bactericidal activity providing opportunities to develop new generation of antibiotics. However their use is limited either by poor metabolic stability or high hemolytic activity. We herein addressed… read more here.
Keywords: physicochemical properties; thiazole based; tailoring physicochemical; based peptide ... See more keywords
Synthesis and Biological Evaluation of Thiazole-Based Fibroblast Growth Factor Receptor-1 Inhibitors.
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DOI: 10.2174/1871520622666220905141248
Abstract: BACKGROUND The Fibroblast Growth Factor Receptor-1 (FGFR-1) is a tyrosine kinase and a validated target for treatment of different cancer types. OBJECTIVE Design and synthesis of novel thiazole-based analogues of anticancer agents. METHODS Series of… read more here.
Keywords: factor receptor; growth factor; thiazole based; fibroblast growth ... See more keywords
Synthesis and Biological Evaluation of Thiazole-Based Derivatives with Potential against Breast Cancer and Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179844
Abstract: Investigating novel, biologically-active coordination compounds that may be useful in the design of breast anticancer, antifungal, and antimicrobial agents is still the main challenge for chemists. In order to get closer to solving this problem,… read more here.
Keywords: synthesis biological; based derivatives; spectroscopy; breast ... See more keywords