Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes
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DOI: 10.1021/acs.jmedchem.2c01591
Abstract: The existence of multiple centrosomes in some cancer cells can lead to cell death through the formation of multipolar mitotic spindles and consequent aberrant cell division. Many cancer cells rely on HSET (KIFC1) to cluster… read more here.
Keywords: thiazole carboxylate; hset kifc1; chemistry; target engagement ... See more keywords