Novel Pyrazoline and Pyrazoline–Thiazole Derivatives Linked to Tetrahydronaphthalene Ring: Synthesis, Anticancer Evaluation, VEGFR ‐2 Inhibition Activity, and Molecular Docking Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70123
Abstract: A new series of pyrazoline and pyrazoline–thiazole derivatives conjugated with tetralin ring 5a, b–19 was created starting with the chalcones 3a , b . The new compounds were tested as potential anticancer agents on three… read more here.
Keywords: molecular docking; pyrazoline thiazole; pyrazoline pyrazoline; thiazole derivatives ... See more keywords
Synthesis and Solvatochromism of New Thiazole Derivatives Bearing N,N-Bis(2-methoxyethyl) Benzenesulfonamide Moiety.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of fluorescence"
DOI: 10.1007/s10895-025-04430-8
Abstract: New thiazole derivatives containing N, N-bis(2-methoxyethyl)benzenesulfonamide groups at the C(4) atom and amino groups bearing electron-donating and electron-withdrawing substituents at the C(2) atom of the heterocycle were obtained via a three-step synthetic method. The sulfonamide… read more here.
Keywords: bis methoxyethyl; solvent polarity; methoxyethyl benzenesulfonamide; thiazole derivatives ... See more keywords
Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.006
Abstract: We have designed novel tropinone-thiazole derivatives that showed high antiproliferative activity against a variety of cancer cell lines via caspase 3/7 activation mechanism. Among the derivatives, compounds 3b-3h were found to exhibit high activity against… read more here.
Keywords: activity; tropinone thiazole; thiazole derivatives; antiproliferative activity ... See more keywords
A novel access to 4-trifluoromethyl-1,3-thiazole derivatives via an intermediate thiocarbonyl ylide
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2019.02.003
Abstract: Abstract A Lewis acid catalyzed reaction of trifluoroacetyldiazomethane (CF3COCHN2) with thiourea occurs in boiling THF solution in the presence of BF3·OEt2 yielding 2-amino-4-trifluoromethyl-1,3-thiazole in a fair yield. Analogous reactions with aromatic thioamides, performed in the… read more here.
Keywords: trifluoromethyl thiazole; thiazole derivatives; access trifluoromethyl; derivatives via ... See more keywords
Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
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DOI: 10.1021/acsomega.2c05077
Abstract: A new series of 2,4-disubstituted thiazole derivatives containing 4-(3,4,5-trimethoxyphenyl) moiety was synthesized and evaluated for their potential anticancer activity as tubulin polymerization inhibitors. All designed compounds were screened for cytotoxic activity against four human cancer… read more here.
Keywords: molecular docking; polymerization inhibitors; thiazole derivatives; activity ... See more keywords
Design, synthesis and docking studies of novel thiazole derivatives incorporating pyridine moiety and assessment as antimicrobial agents
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86424-7
Abstract: A novel series of substituted 4,6-dimethyl-2-oxo-1-(thiazol-2-ylamino)-1,2-dihydropyridine-3-carbonitrile derivatives 6, 9, 13, 15, and 17 was synthesized in a good to excellent yield from the reaction of 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)thiourea with 2-oxo-N'-arylpropanehydrazonoyl chloride, chloroacetone, α-bromoketones, ethyl chloroacetate, and 2,3-dichloroquinoxaline,… read more here.
Keywords: design synthesis; studies novel; synthesis docking; docking studies ... See more keywords
Modular synthesis of thiazoline and thiazole derivatives by using a cascade protocol
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DOI: 10.1039/c7ra05993k
Abstract: The first common synthetic protocol for thiazolines and thiazoles. read more here.
Keywords: modular synthesis; protocol; synthesis thiazoline; thiazoline thiazole ... See more keywords
Synthesis, characterization, biological activities, and computational studies of pyrazolyl–thiazole derivatives of thiophene
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DOI: 10.1039/d4ra06228k
Abstract: This study reports the synthesis, characterization, and biological evaluation of a series of pyrazolyl–thiazole derivatives of thiophene. Seven compounds were synthesized and characterized using NMR spectroscopy and mass spectrometry. The antimicrobial activities of these derivatives… read more here.
Keywords: derivatives thiophene; characterization biological; pyrazolyl thiazole; synthesis characterization ... See more keywords
Novel 2-(2-hydrazinyl)thiazole derivatives as chemotherapeutic agents
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic Communications"
DOI: 10.1080/00397911.2020.1791344
Abstract: Abstract A series of 2-(2-hydrazinyl)thiazole derivatives containing diarylsulfide moiety were synthesized and investigated for their antibacterial and antifungal activities. Compound 3j, namely 2-[2-[4-((4-fluorophenyl)thio)benzylidene]hydrazinyl]-4-(4-methylphenyl)thiazole was determined as the most potent antifungal agent. It was further tested… read more here.
Keywords: novel hydrazinyl; chemotherapeutic agents; hydrazinyl thiazole; derivatives chemotherapeutic ... See more keywords
Synthesis, in vitro-antimicrobial investigation, molecular docking, and DFT studies of novel bis-thiazole derivatives
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DOI: 10.1080/00397911.2024.2387124
Abstract: Abstract Two series of bis-thiazole derivatives (7a–f and 9a–j) were synthesized efficiently via two steps. First, the condensation of 3,3’-(alkane-diylbis(oxy)) dibenzaldehyde (3a,b) with hydrazinecarbothioamide (4) affording 2,2’-(((alkane-1,2-diylbis(oxy))bis(3,1-phenylene))bis(methaneylylidene))bis(hydrazine-1-carbothioamide) (5a,b). The formed 5a,b were then mixed with… read more here.
Keywords: synthesis vitro; investigation; bis thiazole; thiazole derivatives ... See more keywords
Anti-viral activity of thiazole derivatives: an updated patent review.
Sign Up to like & getrecommendations! Published in 2022 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2022.2067477
Abstract: INTRODUCTION : Several viral infections cause life-threatening consequences in humans, making them the most serious worldwide public health concerns. Despite the fact that several antiviral medicines are available on the market, there is no full… read more here.
Keywords: review; thiazole derivatives; viral infections; activity ... See more keywords