Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.038
Abstract: Quinoline derivatives 2, 3, quinolinyl based pyrazolines 4a,b, 5 and quinolinyl pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their anti-proliferative activity against MCF-7, HeLa and DLD1 cancer cell lines as… read more here.
Keywords: anti proliferative; egfr inhibitors; quinoline; thiazole hybrids ... See more keywords
Novel 2-arylthiazolidin-4-one-thiazole hybrids with potent activity against Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105809
Abstract: Substituted aldehydes, ethyl 2-(2-amino-thiazol-4-yl)acetate), and 2-mercaptoacetic acid, in a three-component one-pot green synthetic approach afforded 2-arylthiazolidin-4-one- thiazole hybrids(T1-T13). Compounds showed good anti-tubercular activity towards sensitive M. tuberculosis strain. Compound T8 was as potent as isoniazide… read more here.
Keywords: activity; tuberculosis; thiazole hybrids; arylthiazolidin one ... See more keywords
Ultrasound-assisted synthesis of new triazole-thiazole hybrids: Molecular modeling, anticancer, and antiviral activities
Sign Up to like & getrecommendations! Published in 2025 at "Arabian Journal of Chemistry"
DOI: 10.25259/ajc_306_2024
Abstract: A series of triazole-thiazole hybrids 3, 4, and 5 were synthesized by applying ultrasonic irradiation methodology to the reactions of triazolyl-3-oxo-N-phenylpropanethioamides 2a or 2b with ethyl chloroacetate, chloroacetone, and/or 3-chloroacetylacetone. Density functional theory (DFT) exploration… read more here.
Keywords: triazole thiazole; ultrasound assisted; synthesis new; thiazole hybrids ... See more keywords
New naphthalene-linked pyrazoline–thiazole hybrids as prominent antilung and antibreast cancer inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Turkish Journal of Chemistry"
DOI: 10.55730/1300-0527.3704
Abstract: The epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), pioneer members of the receptor tyrosine kinase subfamily, are frequently mutated and/or overexpressed in several types of human cancers, including nonsmall… read more here.
Keywords: cancer; pyrazoline thiazole; linked pyrazoline; thiazole hybrids ... See more keywords