Thiazole inhibitors of α-glucosidase: Positional isomerism modulates selectivity, enzyme binding and potency of inhibition.
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DOI: 10.1016/j.compbiolchem.2022.107647
Abstract: Isomerism plays a key role in determining potency, selectivity and type of inhibition exhibited by enzyme inhibitors. We present 20 new benzylidene-hydrazinyl-thiazole inhibitors of α-glucosidase featuring positional isomerism of the methyl group at 3 and… read more here.
Keywords: enzyme; thiazole inhibitors; selectivity; inhibition ... See more keywords