Macrocyclization of bioactive peptides with internal thiazole motifs via palladium-catalyzed C-H olefination.
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DOI: 10.1039/d1cc06764h
Abstract: Peptides containing thiazole fragments represent a large group of bioactive compounds with potential medicinal applications. However, methods for efficient synthesis of these compounds with structural diversity are limited. Herein, we report a method for modification… read more here.
Keywords: macrocyclization bioactive; thiazole motifs; palladium catalyzed; olefination ... See more keywords