Synthesis, antimycobacterial, cytotoxicity, anti‐inflammatory, in silico studies and molecular dynamics of pyrazole‐embedded thiazolidin‐4‐one hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200444
Abstract: In the present investigation, we devolved and synthesized a new series of pyrazole‐embedded thiazolidin‐4‐one derivatives (9a–p) with the goal to produce promising antitubercular leads. The in vitro antimycobacterial activity of the synthesized compounds was tested… read more here.
Keywords: thiazolidin one; pyrazole embedded; anti inflammatory; embedded thiazolidin ... See more keywords
2-(3,4-Dichlorophenylimino)-5-((3-(p-substitutedphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidin-4-one as an Antibacterial, Antifungal and Antimycobacterial Agent
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2889
Abstract: 2-(3,4-Dichlorophenylimino)-5-((3-(p-substitutedphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene) thiazolidin-4-one has been selected as a target bio-active molecules. Newly synthesized compounds were screened with Eschericha coli (MTCC 443), Pseudomonas aeruginosa (MTCC 1688), Staphylococcus aureus (MTCC 96), Streptococcus pyogenes (MTCC 442) for antibacterial, Candida… read more here.
Keywords: pyrazol methylene; substitutedphenyl phenyl; methylene thiazolidin; dichlorophenylimino substitutedphenyl ... See more keywords
Effect of Thiazolidin-4-one Against Lipopolysaccharide-Induced Oxidative Damage, and Alterations in Adenine Nucleotide Hydrolysis and Acetylcholinesterase Activity in Cultured Astrocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01177-1
Abstract: Astrocytes play multiple important roles in brain physiology. However, depending on the stimuli, astrocytes may exacerbate inflammatory reactions, contributing to the development and progression of neurological diseases. Therefore, therapies targeting astrocytes represent a promising area… read more here.
Keywords: damage; acetylcholinesterase; effect; activity ... See more keywords
Novel 2-phenyl-3-(Pyridin-2-yl) thiazolidin-4-one derivatives as potent inhibitors for proliferation of osteosarcoma cells in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.114010
Abstract: Due to unknown pathogenesis and unidentified drug target, no drug for the treatment of osteosarcoma (OS) has been launched to the market. Herein, thiazolidinone 1a was discovered as a hit compound by phenotypic screening with… read more here.
Keywords: derivatives potent; one derivatives; phenyl pyridin; thiazolidin one ... See more keywords
A novel series of 1, 4-Dihydropyridine (DHP) derivatives bearing thiazolidin-4-one: From synthesis to structure
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.03.005
Abstract: Abstract A novel series of 1, 4-Dihydropyridine (DHP) thiazolidin-4-one compounds derived from dihydropyridine hydrazones Schiff bases with thioglycolic acid were synthesized through an efficient Hantzsch reaction and experimentally characterized by spectral methods using IR, 1H… read more here.
Keywords: series dihydropyridine; thiazolidin one; dihydropyridine dhp; novel series ... See more keywords
Experimental and theoretical studies of a pyrazole-thiazolidin-2,4-di-one hybrid
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DOI: 10.1016/j.molstruc.2017.03.100
Abstract: Abstract The present work describes synthesis, characterization and biological evaluations of a hybrid compound 10 composed of two intriguing scaffolds pyrazole and thiazolidin-2,4-di-one. The title compound was obtained via multi-step reaction and characterized by a… read more here.
Keywords: studies pyrazole; theoretical studies; pyrazole thiazolidin; thiazolidin one ... See more keywords
Spectroscopic (FT-IR,1H and 13C NMR) characterization and density functional theory calculations for (Z)-5-(4-nitrobenzyliden)-3-N(2-ethoxyphenyl)-2-thioxo-thiazolidin-4-one (ARNO)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.06.102
Abstract: Abstract In this work, the vibrational spectral analysis is carried out by using FTIR spectroscopy in the range 4000–400 cm−1 (Z)-5-(4-nitrobenzyliden)-3-N(2-ethoxyphenyl)-2-thioxo-thiazolidin-4-one (ARNO) molecule. Theoretical calculations were performed by using density functional theory (DFT) method using 6-31G… read more here.
Keywords: density functional; thioxo thiazolidin; ethoxyphenyl thioxo; thiazolidin one ... See more keywords
Crystal structure and NLO properties of the novel tetranuclear copper(I) chloride π-complex with 3-allyl-2-(allylimino)-1,3-thiazolidin-4-one
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DOI: 10.1016/j.molstruc.2018.06.017
Abstract: Abstract By means of alternating current-electrochemical synthesis novel Cu(I) π-complex of the composition [Cu4(dapt)2Cl4]∙0.38EtOH (dapt – (2Z)-3-allyl-2-(allylimino)-1,3-thiazolidin-4-one was obtained and studied by X-ray single crystal diffraction and IR-spectroscopy. π-Complex crystallizes in the trigonal centrosymmetric space… read more here.
Keywords: crystal structure; thiazolidin one; allylimino thiazolidin; allyl allylimino ... See more keywords
Synthesis, crystal structural determination and in silco biological studies of 3,3′-ethane-1,2-diylbis(2-benzylidene-1,3-thiazolidin-4-one
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DOI: 10.1016/j.molstruc.2021.130997
Abstract: Abstract A new thiazolidine derivative, 3,3′-ethane-1,2-diylbis(2-benzylidene-1,3-thiazolidin-4-one (4) was synthesized and the product obtained was characterized by NMR, IR and mass spectral studies, and the structure was confirmed by single crystal X-ray diffraction studies. The title… read more here.
Keywords: thiazolidin one; benzylidene thiazolidin; diylbis benzylidene; structure ... See more keywords
Silica catalyzed one pot synthesis of hybrid thiazolidin-4-one derivatives as anti-tubercular and anti-inflammatory agent by attenuating COX-2 pathway
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DOI: 10.1080/00397911.2019.1643485
Abstract: Abstract A novel series of a hybrid class of hybrid thiazolidin-4-one derivatives were designed and synthesized through one-pot catalytic synthesis. The reaction was catalyzed in the presence of silica-H2SO4(+6). The derivatives computational ADMET profile was… read more here.
Keywords: anti inflammatory; thiazolidin one; one derivatives; hybrid thiazolidin ... See more keywords
Antibacterial and antibiofilm activities of thiazolidine‐2,4‐dione and 4‐thioxo‐thiazolidin‐2‐one derivatives against multidrug‐resistant Staphylococcus aureus clinical isolates
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15790
Abstract: Antimicrobial resistance is one of the highest priorities in global public health with Staphylococcus aureus among the most important microorganisms due to its rapidly evolving antimicrobial resistance. Despite all the efforts of antimicrobial stewardship, research… read more here.
Keywords: thiazolidin one; thioxo thiazolidin; dione thioxo; thiazolidine dione ... See more keywords