The antinociceptive evaluation of 2,3-substituted-1,3-thiazolidin-4-ones through thermal stimulation in mice
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2052-1
Abstract: The present study assessed the 2,3-substituted-1,3-thiazolidin-4-ones antinociceptive potential looking at the acute nociception model induced by thermal stimulation in mice. This was done to contribute to the development of new analgesic drugs, in addition to… read more here.
Keywords: substituted thiazolidin; thermal stimulation; thiazolidin ones; stimulation mice ... See more keywords
A convenient and efficient synthesis of thiazolidin-4-ones via cyclization of substituted hydrazinecarbothioamides
Sign Up to like & getrecommendations! Published in 2019 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2014.10.035
Abstract: Abstract 2-Substituted hydrazinecarbothioamides and N,2-disubstituted hydrazinecarbothioamides react in high yield with dimethyl acetylenedicarboxylate (DMAD) to give 4-oxo-Z-(thiazolidin-5-ylidene) acetate derivatives. Several mechanistic options involving interaction are presented. The structures of thiazolidin-4-ones have been unambiguously confirmed by… read more here.
Keywords: convenient efficient; efficient synthesis; substituted hydrazinecarbothioamides; synthesis thiazolidin ... See more keywords