Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103128
Abstract: α-Glucosidase is considered as a therapeutic target for the treatment of type 2 diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2,5-dione (succinimide) and thiazolidine-2,4-dione derivatives and evaluated for their ability to inhibit α-Glucosidase. Pyrrolidine-2,5-dione… read more here.
Keywords: pyrrolidine dione; dione; thiazolidine dione; dione derivatives ... See more keywords
Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl)methylene]-thiazolidine-2,4-dione derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Heliyon"
DOI: 10.1016/j.heliyon.2018.e00807
Abstract: Abstract Various thiazolidine-2,4-dione derivatives 3a-l possessing indole moiety were designed, synthesized using appropriate conventional heating as well as microwave irradiation methods. All the synthesized compounds were characterized physically and spectrally. The compounds were evaluated for… read more here.
Keywords: docking studies; thiazolidine dione; dione derivatives; activity ... See more keywords
Thiazolidine-2,4-dione derivative in 2-hydroxypropyl-β-cyclodextrin solutions: Complexation/solubilization, distribution and permeability
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115931
Abstract: Abstract Since a majority of drug substances are poor soluble in aqueous solutions, suitable drug formulations are often used. Among others, the cyclodextrin-based pharmaceutical products have been shown to be successful for a large variety… read more here.
Keywords: buffer; thiazolidine dione; hydroxypropyl cyclodextrin; permeability ... See more keywords
Regioselectivity evaluation of the (Z)-5-(4-hydroxybenzylidene)-thiazolidine-2,4‑dione alkylation in alkaline environment
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130629
Abstract: Abstract Thiazolidine-2,4‑dione represents a key heterocyclic core in medicinal chemistry because it has the ability to bind to a wide variety of protein targets and has been intensively studied for developing bioactive multitargeting agents. The… read more here.
Keywords: dione; alkylation; thiazolidine dione; hydroxybenzylidene thiazolidine ... See more keywords
Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "MedChemComm"
DOI: 10.1039/c7md00173h
Abstract: A series of novel thiazolidine-2,4-dione or rhodanine derivatives (5a-5k, 6a-6k) were synthesized and evaluated for their α-glucosidase inhibitory activity. The majority of compounds exhibited potent inhibitory activity in the range of 5.44 ± 0.13 to… read more here.
Keywords: dione rhodanine; rhodanine; thiazolidine dione; molecular docking ... See more keywords
Antibacterial and antibiofilm activities of thiazolidine‐2,4‐dione and 4‐thioxo‐thiazolidin‐2‐one derivatives against multidrug‐resistant Staphylococcus aureus clinical isolates
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15790
Abstract: Antimicrobial resistance is one of the highest priorities in global public health with Staphylococcus aureus among the most important microorganisms due to its rapidly evolving antimicrobial resistance. Despite all the efforts of antimicrobial stewardship, research… read more here.
Keywords: thiazolidin one; thioxo thiazolidin; dione thioxo; thiazolidine dione ... See more keywords
Synthesis and antimicrobial activity of novel 5-[(1H-indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrids
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s107036321702027x
Abstract: Abstract5-[(1H-Indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrid derivatives were synthesized by click chemistry reaction and screened for antimicrobial activity against Gram positive and Gram negative bacteria and fungal species. All synthesized compounds were characterized by 1H and 13C NMR, IR… read more here.
Keywords: thiazolidine dione; chemistry; activity; indol methylene ... See more keywords
Design, Synthesis, Hypoglycemic Activity and Molecular Docking Studies of 3-substituted-5- [(furan-2-yl)-methylene]-thiazolidine-2,4-dione Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.55.1.30
Abstract: Background: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our attempt all the titled compounds were designed and developed by… read more here.
Keywords: thiazolidine dione; molecular docking; furan methylene; activity ... See more keywords