A quantum chemical study of the interactions of uracil as a constituent of ribonucleic acid (RNA) with thiazolidinedione and rhodanine bioactive molecules: an insight into energetic and structural features
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DOI: 10.1007/s11224-017-1062-4
Abstract: In this study, the biologically active configurations composed of Thiazolidinedione–Uracil (TU) and Rhodanine–Uracil (RU) have been fully investigated from the energetic and structural points of view, employing B3LYP and M062X functionals in combination with the… read more here.
Keywords: energetic structural; energy; study; interaction energy ... See more keywords
Binding mode exploration of LuxR-thiazolidinedione analogues, e-pharmacophore-based virtual screening in the designing of LuxR inhibitors and its biological evaluation
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DOI: 10.1080/07391102.2016.1166455
Abstract: Master quorum sensing (QS) regulator LuxR of Vibrio harveyi is a unique member of the TetR protein superfamily. Recent studies have demonstrated the contribution of thiazolidinedione analogues in blocking QS by decreasing the DNA-binding ability… read more here.
Keywords: chembridge 5343641; thiazolidinedione analogues; mode exploration; binding mode ... See more keywords
Association of thiazolidinedione with a lower risk of Parkinson’s disease in a population with newly-diagnosed diabetes mellitus
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DOI: 10.1080/07853890.2018.1488083
Abstract: Abstract Objectives: We investigated the association of thiazolidinedione and its dose effect with the risk of Parkinson’s disease (PD) in patients with diabetes mellitus (DM). Methods: This study enrolled 38,521 patients with newly-diagnosed DM, between… read more here.
Keywords: risk; newly diagnosed; risk parkinson; diabetes mellitus ... See more keywords