A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions
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DOI: 10.1039/c7qo00751e
Abstract: 4-(2-Substituted-[1,3]thiazolo[3,2-a]benzimidazol-3-yl)quinazolin-2-amines were prepared by the multi-component reaction of 2,4-dichloroquinazoline, terminal alkynes, secondary amines, and 1H-benzo[d]imidazole-2(3H)-thione in the presence of a palladium–copper catalyst. This one-pot process provided an efficient and successful approach for the synthesis of… read more here.
Keywords: thiazolo benzimidazole; linked quinazoline; benzimidazole linked; one pot ... See more keywords