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1
Published in 2019 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363219010067
Abstract: Heterocyclization of 3-[(1H-1,2,4-triazol-3-yl)thio]pentane-2,4-dione afforded 1-(6-methylthiazolo[3,2-b][1,2,4]-triazol-5-yl)ethan-1-one, the reactions of which with hydroxylamine, hydrazincarboxamide, hydrazincarbothioamide, hydrazine hydrate and para-toluenesulfonyl hydrazide resulted in the formation of the corresponding derivatives. 1-(6-Methylthiazolo[3,2-b][1,2,4]triazol-5-yl)ethan-1-one oxime reacted with alkyl halides and phenyl isocyanate…
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Keywords:
triazole derivatives;
derivatives preliminary;
new thiazolo;
synthesis new ... See more keywords
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2
Published in 2021 at "Molecules"
DOI: 10.3390/molecules26041162
Abstract: The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-b][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-b][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage…
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Keywords:
vitro evaluation;
anticancer;
characterization vitro;
thiazolo triazole ... See more keywords
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2
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051464
Abstract: Many nitrogen- and sulfur-containing heterocyclic compounds exhibit biological activity. Among these heterocycles are benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles for which two main synthetic approaches exist. Here we report a new synthetic protocol that allows the preparation of these tricyclic…
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Keywords:
benzo thiazolo;
bond functionalization;
synthesis benzo;
thiazolo triazole ... See more keywords