Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis
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DOI: 10.1038/s41598-019-48300-3
Abstract: Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is the most abundant protein in normal urine. Defective uromodulin processing is associated with various kidney… read more here.
Keywords: salt; hepsin; uromodulin; thick ascending ... See more keywords
Heterogeneity of tight junctions in the thick ascending limb
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DOI: 10.1111/nyas.13400
Abstract: Renal tubular transport mechanisms are optimized to be energy efficient and tailored to local gradients and transport rates. The combined transcellular action of ion channels, transporters, and pumps, together with the paracellular pathway, enables kidney… read more here.
Keywords: junctions thick; heterogeneity tight; tight junctions; ascending limb ... See more keywords
Unrecognized role of claudin‐10b in basolateral membrane infoldings of the thick ascending limb
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DOI: 10.1111/nyas.14882
Abstract: Claudin‐10b is an important component of the tight junction in the thick ascending limb (TAL) of Henle's loop and allows paracellular sodium transport. In immunofluorescence stainings, claudin‐10b–positive cells exhibited extensive extra staining of basolateral, column‐like… read more here.
Keywords: microscopy; ascending limb; thick ascending; claudin 10b ... See more keywords
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption
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DOI: 10.1152/ajprenal.00119.2024
Abstract: In the kidney, the thick Ascending Limb (TAL) of the loop of Henle is crucial for NaCl homeostasis and blood pressure regulation. In animal models of salt-sensitive hypertension, NaCl reabsorption via the apical Na+/K+/2Cl cotransporter… read more here.
Keywords: physiology; thick ascending; nacl reabsorption; actn4 ... See more keywords
A novel mouse model for an inducible gene modification in the renal thick ascending limb
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Physiology - Renal Physiology"
DOI: 10.1152/ajprenal.00250.2022
Abstract: The thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant… read more here.
Keywords: mouse; gene modification; thick ascending; physiology ... See more keywords
Nonmuscle myosin II proteins, Myh9 and Myh10, interacts with unconventional myosin Myo18A in immortalized mouse thick ascending limb epithelial cells
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DOI: 10.1152/physiol.2023.38.s1.5732503
Abstract: Conventional nonmuscle myosin II (NM2) and unconventional myosin 18A (Myo18A) belong to an evolutionarily conserved family of molecular motor proteins that slide or walk on the actin cytoskeleton to facilitate a myriad of cellular functions… read more here.
Keywords: mouse; ascending limb; thick ascending; physiology ... See more keywords
Novel electron and super resolution microscopy techniques reveal unique cellular and organelle architecture regulated by myosin motors within murine thick ascending limb
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DOI: 10.1152/physiol.2025.40.s1.0595
Abstract: We recently confirmed that myosin motor proteins Myh9 and Myh10 ( Myh9&10 ) are crucial for proper cargo protein trafficking in the thick ascending limb (TAL) of adult mouse kidney. TAL-specific conditional knockout of Myh9&10… read more here.
Keywords: architecture; physiology; microscopy; thick ascending ... See more keywords
Inhibitory effect of S-nitroso-N-acetylpenicillamine on the basolateral 10-pS Cl- channel in thick ascending limb
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DOI: 10.1371/journal.pone.0284707
Abstract: We have previously reported that L-arginine, a nitric oxide synthase substrate, inhibits the basolateral 10-pS Cl- channel through the cGMP/PKG signaling pathway in the thick ascending limb (TAL). As a NO releasing agent, the effect… read more here.
Keywords: inhibitory effect; effect; ascending limb; thick ascending ... See more keywords