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Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48300-3
Abstract: Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is the most abundant protein in normal urine. Defective uromodulin processing is associated with various kidney…
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Keywords:
salt;
hepsin;
uromodulin;
thick ascending ... See more keywords
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1
Published in 2017 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.13400
Abstract: Renal tubular transport mechanisms are optimized to be energy efficient and tailored to local gradients and transport rates. The combined transcellular action of ion channels, transporters, and pumps, together with the paracellular pathway, enables kidney…
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Keywords:
junctions thick;
heterogeneity tight;
tight junctions;
ascending limb ... See more keywords
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2
Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14882
Abstract: Claudin‐10b is an important component of the tight junction in the thick ascending limb (TAL) of Henle's loop and allows paracellular sodium transport. In immunofluorescence stainings, claudin‐10b–positive cells exhibited extensive extra staining of basolateral, column‐like…
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Keywords:
microscopy;
ascending limb;
thick ascending;
claudin 10b ... See more keywords
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3
Published in 2023 at "American Journal of Physiology - Renal Physiology"
DOI: 10.1152/ajprenal.00250.2022
Abstract: The thick ascending limb (TAL) is critical for the renal control of fluid and ion homeostasis. The function of the TAL depends on the activity of the bumetanide-sensitive Na-K-2Cl co-transporter NKCC2, which is highly abundant…
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Keywords:
mouse;
gene modification;
thick ascending;
physiology ... See more keywords
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2
Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732503
Abstract: Conventional nonmuscle myosin II (NM2) and unconventional myosin 18A (Myo18A) belong to an evolutionarily conserved family of molecular motor proteins that slide or walk on the actin cytoskeleton to facilitate a myriad of cellular functions…
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Keywords:
mouse;
ascending limb;
thick ascending;
physiology ... See more keywords
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2
Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0284707
Abstract: We have previously reported that L-arginine, a nitric oxide synthase substrate, inhibits the basolateral 10-pS Cl- channel through the cGMP/PKG signaling pathway in the thick ascending limb (TAL). As a NO releasing agent, the effect…
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Keywords:
inhibitory effect;
effect;
ascending limb;
thick ascending ... See more keywords