Thick filament‐associated myosin undergoes frequent replacement at the tip of the thick filament
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DOI: 10.1002/2211-5463.13379
Abstract: Myosin plays a fundamental role in muscle contraction. Approximately 300 myosins form a bipolar thick filament, in which myosin is continuously replaced by protein turnover. However, it is unclear how rapidly this process occurs and… read more here.
Keywords: myosin release; thick filament; myosin; tip thick ... See more keywords
The Role of the Thick Filaments in the Regulation of Muscle Contraction
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DOI: 10.1016/j.bpj.2016.11.084
Abstract: Contraction of skeletal and heart muscle is triggered by a calcium-dependent structural change in the actin-containing thin filaments that permits binding of myosin motors from the neighbouring thick filaments. In resting muscle, however, most of… read more here.
Keywords: thick filaments; muscle; thick filament; contraction ... See more keywords
Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular and Cellular Cardiology"
DOI: 10.1016/j.yjmcc.2018.02.009
Abstract: Hypertrophic cardiomyopathy (HCM) is frequently linked to mutations in the protein components of the myosin-containing thick filaments leading to contractile dysfunction and ultimately heart failure. However, the molecular structure-function relationships that underlie these pathological effects… read more here.
Keywords: mutation; myosin; hypertrophic cardiomyopathy; thick filament ... See more keywords
Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle
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DOI: 10.1038/s41598-017-05999-2
Abstract: Recent experimental evidence in skeletal muscle demonstrated the existence of a thick-filament mechanosensing mechanism, acting as a second regulatory system for muscle contraction, in addition to calcium-mediated thin filament regulation. These two systems cooperate to… read more here.
Keywords: rat trabecula; muscle; thick filament; mechanosensing mechanism ... See more keywords
Ultrastructural and kinetic evidence support that thick filaments slide through the Z-disc
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DOI: 10.1098/rsif.2022.0642
Abstract: How myofilaments operate at short mammalian skeletal muscle lengths is unknown. A common assumption is that thick (myosin-containing) filaments get compressed at the Z-disc. We provide ultrastructural evidence of sarcomeres contracting down to 0.44 µm—approximately… read more here.
Keywords: thick filament; evidence; ultrastructural kinetic; evidence support ... See more keywords
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension.
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DOI: 10.1161/circulationaha.123.064717
Abstract: BACKGROUND Right ventricular (RV) contractile dysfunction commonly occurs and worsens outcomes in patients with heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH). However, such dysfunction often goes undetected by standard clinical RV indices,… read more here.
Keywords: clinical function; heart failure; drx; thick filament ... See more keywords
Structure of the Flight Muscle Thick Filament from the Bumble Bee, Bombus ignitus, at 6 Å Resolution
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DOI: 10.3390/ijms24010377
Abstract: Four insect orders have flight muscles that are both asynchronous and indirect; they are asynchronous in that the wingbeat frequency is decoupled from the frequency of nervous stimulation and indirect in that the muscles attach… read more here.
Keywords: flight muscle; structure; thick filament; myosin ... See more keywords