A convenient synthesis of tetrahydro-1Н-thieno-[3,2-с]pyrazole 4,4-dioxides
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02556-9
Abstract: The reaction of oxidation of 3-aryl-6a-methyl-6-nitrohexahydrothieno[2,3-d]pyrazole 4,4-dioxides by bromine was used to synthesize their derivatives 3-aryl-6a-methyl-6-nitro-3a,5,6,6a-tetrahydro-1H-thieno[3,2-c]pyrazole 4,4-dioxides, the structure of which was established by IR, 1H, 13C, 1H–13C HMQC, 1H–13C HMBC spectroscopy and X-ray structural… read more here.
Keywords: thieno pyrazole; pyrazole dioxides; tetrahydro thieno;
Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro
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DOI: 10.3390/biology11060930
Abstract: Simple Summary Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules. In this study, a screening of 2000 novel molecules revealed a unique thienopyrazole derivative, Tpz-1, that elicited potent and selective… read more here.
Keywords: cell; pyrazole derivative; tpz; thieno pyrazole ... See more keywords