Design, cytotoxicity and toxicity of new thiophene and thieno [2,3-b] pyridine derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1780-6
Abstract: Novel thiophene derivatives 3a–f were synthesized by using the 3-oxo-3-propanenitrile derivatives 1a–c with triethylamine, elemental sulfur and either of malononitrile or ethyl cyanoacetate. Compounds 3a, 3c, and 3e were reacted with ethyl cyanoacetate to give… read more here.
Keywords: thiophene; design cytotoxicity; cancer; thieno pyridine ... See more keywords
Synthesis of 2-(1-aryl-1H-tetrazol-5-yl)-thieno[2,3-b]pyridine derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02533-2
Abstract: Alkylation of 4,6-dimethyl-2-sulfanylpyridine-3-carbonitrile with 1-aryl-5-(chloromethyl)-1H-tetrazoles yielded 2-{[(1-aryl-1H-tetrazol-5-yl)methyl]sulfanyl}-4,6-dimethylpyridine-3-carbonitriles, which easily cyclize by the action of bases to form 2-(1H-tetrazol-5-yl)-thieno[2,3-b]pyridine derivatives. The use of excess base in the alkylation step leads to direct formation of cyclized products… read more here.
Keywords: aryl tetrazol; thieno pyridine; tetrazol thieno; pyridine derivatives ... See more keywords
Tandem synthesis and antibacterial screening of new thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones linked to thiazole or oxazole units
Sign Up to like & getrecommendations! Published in 2023 at "Synthetic Communications"
DOI: 10.1080/00397911.2023.2204192
Abstract: Abstract New two series of thieno[2,3-b]pyridine-fused pyrimidinones 1 and 2 linked to thiazole or oxazole units were prepared utilizing a three-component tandem protocol. Therefore, a mixture of 1 equiv. of 3-aminothieno[2,3-b]pyridine-2-carboxylate was first microwave irradiated… read more here.
Keywords: thiazole oxazole; pyridine fused; thieno pyridine; oxazole units ... See more keywords
Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2018.1457657
Abstract: Abstract In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors of the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5-lipoxygensase (5-LOX). Testing these compounds in a rat paw… read more here.
Keywords: eicosanoid biosynthesis; inhibition; cox; molecular modelling ... See more keywords
New bis(thieno[2,3-b]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2022-0236
Abstract: Using sonication and mediated by piperazine, new arene-linked bis(thieno[2,3-b]pyridine) hybrids were efficiently prepared in this study. The target hybrids were prepared by reacting bis(α-haloketone) with two equivalents of the appropriate pyridine-2(1H)-thiones in the presence of… read more here.
Keywords: bis thieno; pyridine hybrids; biofilm; thieno pyridine ... See more keywords
Design, Molecular Modeling and Synthesis of Metal-Free Sensitizers of Thieno Pyridine Dyes as Light-Harvesting Materials with Efficiency Improvement Using Plasmonic Nanoparticles
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25081813
Abstract: Considering the thiophene unit as an electron-rich heterocycle, it is investigated with the aim of elucidating its potential efficiency for solar cell application. With the introduction of active substituents such as COOEt, CONH2 and CN… read more here.
Keywords: molecular modeling; efficiency improvement; metal; thieno pyridine ... See more keywords