Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.03.060
Abstract: Urea transporters (UTs) play an important role in the urine concentrating mechanism and are recognized as novel targets for developing small molecule inhibitors with salt-sparing diuretic activity. Thienoquinoline derivatives, a class of novel UT-B inhibitors… read more here.
Keywords: transporter inhibitors; discovery optimization; thienopyridine derivatives; urea transporter ... See more keywords
Quantum mechanics and 3D-QSAR studies on thienopyridine analogues: inhibitors of IKKβ
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04125
Abstract: Inhibitor of kappa B kinase subunit β (IKKβ) is a main regulator of nuclear factor kappa B (NF-κB) and has received considerable attention as an attractive therapeutic target for the treatment of lung cancer or… read more here.
Keywords: biological activity; thienopyridine derivatives; quantum mechanics; activity ... See more keywords