Mechanism of thienopyridone and iminothienopyridinedione inhibition of protein phosphatases.
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DOI: 10.1039/c9md00175a
Abstract: Thienopyridone (TP) has been proposed as a selective inhibitor of phosphatases of regenerating liver (PRL or PTP4A). PRLs are dual specificity phosphatases that promote cancer progression and are attractive anticancer targets. TP and iminothienopyridinedione (ITP),… read more here.
Keywords: mechanism thienopyridone; protein phosphatases; thienopyridone; inhibition ... See more keywords