Thienopyrimidine‐based agents bearing diphenylurea: Design, synthesis, and evaluation of antiproliferative and antiangiogenic activity
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DOI: 10.1002/ardp.202200349
Abstract: An important role has been considered for the vascular endothelial growth factor receptor 2 (VEGFR‐2) in the angiogenesis process, so that its inhibition is an important scientific way for cancer treatment. In this work, new… read more here.
Keywords: thienopyrimidine based; bearing diphenylurea; activity; sw480 huvec ... See more keywords
Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01913
Abstract: Novel analogues of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and… read more here.
Keywords: inhibitors human; geranylgeranyl pyrophosphate; thienopyrimidine based; pyrophosphate synthase ... See more keywords