Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.
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DOI: 10.1016/j.ejmech.2017.01.035
Abstract: New thienopyrimidine hydroxamic acid derivatives as HDACs inhibitors were designed, synthesized and evaluated. All compounds were evaluated for their ability to inhibit recombinant human HDAC1, HDAC3, and HDAC6 isoforms and in vitro anti-proliferative activity on tumor… read more here.
Keywords: hct 116; hydroxamic acid; thienopyrimidine hydroxamic; 8226 hct ... See more keywords