Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
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DOI: 10.1038/s41467-021-24049-0
Abstract: Sarcomeres, the basic contractile units of striated muscle, produce the forces driving muscular contraction through cross-bridge interactions between actin-containing thin filaments and myosin II-based thick filaments. Until now, direct visualization of the molecular architecture underlying… read more here.
Keywords: molecular scale; sarcomere contraction; thin filaments; contraction ... See more keywords
Calcium increases titin N2A binding to F-actin and regulated thin filaments
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32952-8
Abstract: Mutations in titin are responsible for many cardiac and muscle diseases, yet the underlying mechanisms remain largely unexplained. Numerous studies have established roles for titin in muscle function, and Ca2+-dependent interactions between titin and actin… read more here.
Keywords: actin; muscle; thin filaments; n2a actin ... See more keywords
CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01893-w
Abstract: The precise assembly of actin-based thin filaments is crucial for muscle contraction. Dysregulation of actin dynamics at thin filament pointed ends results in skeletal and cardiac myopathies. Here, we discovered adenylyl cyclase-associated protein 2 (CAP2)… read more here.
Keywords: actin; muscle; cardiac muscle; thin filaments ... See more keywords
Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin
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DOI: 10.1126/science.abn1934
Abstract: In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the underlying mechanism remains nebulous. In this work, we used cryo–electron tomography and subtomogram averaging to reveal structures of native nebulin bound… read more here.
Keywords: thin filament; muscle; thin filaments; myosin ... See more keywords
Tropomodulin–Tropomyosin Interplay Modulates Interaction Between Cardiac Myosin and Thin Filaments
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DOI: 10.3390/biom15050727
Abstract: Tropomodulin (Tmod) is an actin-binding protein that interacts with tropomyosin and the actin filament at the pointed end. The influence of Tmod on the thin filament activation in the myocardium is not clear. We studied… read more here.
Keywords: myosin; thin filaments; tpm1; velocity ... See more keywords
Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases
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DOI: 10.3390/ijms21020542
Abstract: Sarcomere assembly and maintenance are essential physiological processes required for cardiac and skeletal muscle function and organism mobility. Over decades of research, components of the sarcomere and factors involved in the formation and maintenance of… read more here.
Keywords: sarcomere assembly; filaments associated; assembly maintenance; sarcomere thin ... See more keywords
The Mechanisms of Thin Filament Assembly and Length Regulation in Muscles
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105306
Abstract: The actin containing tropomyosin and troponin decorated thin filaments form one of the crucial components of the contractile apparatus in muscles. The thin filaments are organized into densely packed lattices interdigitated with myosin-based thick filaments.… read more here.
Keywords: mechanisms thin; thin filament; assembly length; thin filaments ... See more keywords