Sustainable polythioesters via thio(no)lactones: monomer synthesis, ring-opening polymerization, end-of-life considerations and industrial perspectives.
Sign Up to like & getrecommendations! Published in 2023 at "ChemSusChem"
DOI: 10.1002/cssc.202202276
Abstract: As the environmental effects of plastics are of ever greater concern, the industry is driven towards more sustainable polymers. Besides sustainability, our fast-developing society imposes the need for highly versatile materials. While aliphatic polyesters (PEs)… read more here.
Keywords: end life; opening polymerization; thio lactones; thio ... See more keywords
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.12.020
Abstract: In search of potent and safe antifungal agents, herein, we report the synthesis, characterization and biological activities of triazole-oxadiazole compounds. The structural verification of the molecules was carried out by 1H NMR, 13C NMR and… read more here.
Keywords: synthesis antifungal; apoptotic effects; triazole oxadiazoles; thio ... See more keywords
Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114345
Abstract: As a key upstream kinase involved in the activation of necroptosis, receptor-interacting protein kinase 1 (RIPK1) plays a vital role in the treatment of relevant inflammatory diseases. Recently, we described the thio-benzoxazepinones as RIPK1 necroptosis… read more here.
Keywords: chemical space; ripk1; thio; investigation chemical ... See more keywords
Structure-Based Design of Novel Alkynyl Thio-Benzoxazepinone Receptor-Interacting Protein Kinase-1 Inhibitors: Extending the Chemical Space from the Allosteric to ATP Binding Pockets.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02067
Abstract: Systemic inflammatory response syndrome (SIRS), characterized by severe systemic inflammation, represents a major cause of health loss, potentially leading to multiple organ failure, shock, and death. Exploring potent RIPK1 inhibitors is an effective therapeutic strategy… read more here.
Keywords: binding pockets; allosteric atp; atp binding; alkynyl ... See more keywords
Scandium catalysed stereoselective thio-allylation of allenyl-imidates.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc04302k
Abstract: The site-selective thio-allylation of electron-deficient 1,2-dienes is documented under scandium catalysis. The methodology enables the realization of α-β unsaturated, β-thio, γ-allyl carboxylic acid derivatives via a one-pot Lewis acid promoted Michael addition/[3,3]-sigmatropic rearrangement sequence (20… read more here.
Keywords: scandium catalysed; stereoselective thio; thio; catalysed stereoselective ... See more keywords
Crystal structure and Hirshfield surface analysis of 4-phenyl-3-(thio-phen-3-ylmeth-yl)-1H-1,2,4-triazole-5(4H)-thione.
Sign Up to like & getrecommendations! Published in 2018 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989018007193
Abstract: In the title compound, C13H11N3S2, the phenyl ring is twisted from the 1,2,4-triazole plane by 63.35 (9)° and by 47.35 (9)° from the thiophene plane. In the crystal, chains of molecules running along the c-axis direction are… read more here.
Keywords: inter actions; hirshfield surface; phenyl; thio ... See more keywords
Abstract 4143: Enhancing adaptive immune responses with telomerase-mediated telomere targeting therapeutics in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4143
Abstract: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and is the third leading cause of cancer-related deaths. In recent years, immune checkpoint inhibitors (ICIs) have improved treatment of solid tumors… read more here.
Keywords: mediated telomere; hepatocellular carcinoma; telomere targeting; telomerase mediated ... See more keywords
Abstract CT050: A phase 2, multi-center, open-label, dose-finding study evaluating telomere targeting agent THIO sequenced with cemiplimab in patients with advanced NSCLC
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct050
Abstract: Background: The modified nucleoside 6-thio-2'-deoxyguanosine (THIO) is a first-in-class direct telomere-targeting agent that is preferentially incorporated in telomeres of telomerase-positive cells, leading to telomere uncapping and cancer cell death. Preclinical evidence indicates that THIO pretreatment… read more here.
Keywords: telomere targeting; targeting agent; patients advanced; thio ... See more keywords
Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12050738
Abstract: New medical treatments are urgently needed for advanced hepatocellular carcinoma (HCC). Recently, we showed the anticancer effects of novel thiophene-based kinase inhibitors. In this study, we further characterized the antineoplastic effects and modes of action… read more here.
Keywords: hepatocellular carcinoma; kinase inhibitors; kinase; thio ... See more keywords
Synthesis and Biological Importance of 2-(thio)ureabenzothiazoles
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27186104
Abstract: The (thio)urea and benzothiazole (BT) derivatives have been shown to have a broad spectrum of biological activities. These groups, when bonded, result in the 2-(thio)ureabenzothizoles (TBT and UBT), which could favor the physicochemical and biological… read more here.
Keywords: synthesis biological; ubts tbts; importance thio; thio ... See more keywords