Stereochemistry of internucleoside phosphorus atom affects sugar pucker and acid hydrolysis of N3′-P5′ thio-phosphoramidates
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DOI: 10.1016/j.tetlet.2021.152834
Abstract: Abstract Investigation of the sugar pucker of the two diastereomers of dinucleotide N3′-P5′-thio-phosphoramidates TNPSTNH2 and TNPSTOH shows that the Sp isomer adopts a more C3′-endo (North) sugar ring configuration than the Rp counterpart. In contrast,… read more here.
Keywords: sugar pucker; acid hydrolysis; thio phosphoramidates; stereochemistry ... See more keywords