2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.
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DOI: 10.1016/j.ejmech.2017.06.020
Abstract: In this work, a series of 2-substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamide derivatives were developed as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. In addition, the selected compounds… read more here.
Keywords: thio substituted; thiazol imidazol; substituted thio; substituted thiazol ... See more keywords
Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)
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DOI: 10.1016/j.neuropharm.2017.07.012
Abstract: BACKGROUND 4-Thio-substituted phenethylamines (2C-T drugs) are potent psychedelics with poorly defined pharmacological properties. Because of their psychedelic effects, 2C-T drugs are sometimes sold as new psychoactive substances (NPSs). The aim of the present study was… read more here.
Keywords: monoamine receptor; phenethylamines drugs; thio substituted; receptor ... See more keywords