Articles with "thioamide thiourea" as a keyword



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Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs.

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Published in 2023 at "Chemical communications"

DOI: 10.1039/d2cc06596g

Abstract: Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for… read more here.

Keywords: thiourea thiocarbamate; thiol reactivity; thioamide thiourea; masking thiol ... See more keywords