Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors.
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DOI: 10.1021/acsmedchemlett.0c00527
Abstract: A structure-activity relationship study unexpectedly showed that carbonothioates 4a and 4b, obtained by a unique alkaline hydrolysis of 2-alkylthio-oxazolines 3a and 3b, respectively, are a novel scaffold for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Derivatization of… read more here.
Keywords: carbono thioates; thioates indoleamine; discovery carbono; dioxygenase ... See more keywords