Exploiting the Thiobarbituric Acid Scaffold for Antibacterial Activity
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800414
Abstract: Thiobarbituric acid (TBA) has been considered a privileged structure for developing antimicrobial agents. Diversity was obtained at positions N and at C5 through acylation, Schiff base formation, Knoevenagel condensation, and thioamide and enamine formation. The… read more here.
Keywords: acid; thiobarbituric acid; acid scaffold; scaffold antibacterial ... See more keywords
On the development of the thiobarbituric acid test for lipid oxidation.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2022.109188
Abstract: This commentary describes a highly cited paper by Dahle, Hill, and Holman, Arch Biochem Biophys. 1962; 98: 253-261. They showed that the oxidation products of polyunsaturated fatty acids reacted with thiobarbituric acid to give a… read more here.
Keywords: oxidation; development thiobarbituric; acid test; test lipid ... See more keywords
Plasma thiobarbituric acid reactive substances predicts survival in chemotherapy naïve patients with metastatic urothelial carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100890
Abstract: Oxidative stress plays a significant role in development and progression of cancer, including urothelial carcinomas. TBARS (Thiobarbituric acid reactive substances) represents a marker of oxidative stress increased in various diseases. In this prospective study, we… read more here.
Keywords: chemotherapy; plasma; thiobarbituric acid; survival chemotherapy ... See more keywords
Supramolecular polymerization of thiobarbituric acid naphthalene dye.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02984g
Abstract: 2-Thiobarbituric acid-functionalized naphthalene dye selectively self-assembles into crystalline fibers to show material properties that are different from those of a previously reported oxo-barbituric acid derivative affording curved supramolecular polymers via the formation of hydrogen-bonded rosettes.… read more here.
Keywords: supramolecular polymerization; acid; polymerization thiobarbituric; thiobarbituric acid ... See more keywords
2-Thiobarbituric acid addition improves structural integrity and controlled drug delivery of biocompatible pectin hydrogels
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2020.1760272
Abstract: Abstract Thiolated polymers are commonly preferred for biomedical applications with their good permeation properties providing them higher bioavailability. However, the thiolation process is mostly time-consuming series of chemical reactions. This study describes a simple irreversible… read more here.
Keywords: pectin hydrogels; thiobarbituric acid; drug; acid addition ... See more keywords
HPLC-TBARS-EVSC (high performance liquid chromatography - thiobarbituric acid reactive substances - ex vivo stratum corneum) protocol: Selection of the subjects and approach to present the results.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of cosmetic science"
DOI: 10.1111/ics.12874
Abstract: OBJECTIVE Nowadays, it is recognized the need for improved safety and efficacy protocols to evaluate the human stratum corneum (SC) and its interaction with topical and cosmetic formulations by minimally or non-invasive methodologies. The aim… read more here.
Keywords: hplc tbars; tbars evsc; thiobarbituric acid; stratum corneum ... See more keywords
Selectivity in the Formation of Straight-Chain Versus Cyclised products on Knoevenagel Condensation between Thiobarbituric acid and Naphthaldehydes
Sign Up to like & getrecommendations! Published in 2021 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2021.00852
Abstract: The prevalence of Clostridium difficile (CD) infection has grown rapidly due to resistance and the emergence of new, highly virulent strains of the organism that have become less sensitive to many antibiotics. Vancomycin and metronidazole… read more here.
Keywords: thiobarbituric acid; straight chain; infection; formation ... See more keywords