Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.
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DOI: 10.1016/j.bioorg.2018.09.004
Abstract: A number of naturally occurring compounds such as paclitaxel, vinblastine, combretastatin, and colchicine exert their therapeutic effect by changing the dynamics of tubulin and its polymer form, microtubules. The identification of tubulin as a potential… read more here.
Keywords: thiocolchicine; molecular docking; antiproliferative activity; synthesis antiproliferative ... See more keywords