Characterization of a thioester-containing protein from the pearl oyster Pinctada fucata and its role in phagocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture Reports"
DOI: 10.1016/j.aqrep.2021.100833
Abstract: Abstract Thioester-containing proteins (TEPs) superfamily is known to play important innate immune functions in vertebrates and invertebrates, and involved in recognition, and killing of invading pathogens. Here, a TEP gene (designated as Pf-TEP) was obtained… read more here.
Keywords: protein; tep; thioester containing; pearl oyster ... See more keywords
Anti-TNF Thioester Glucocorticoid Antibody-Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00598
Abstract: We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody-drug conjugate (ADC). Payload 6 was designed for rapid hepatic inactivation to minimize systemic exposure of nonconjugated GRM. Mouse PK… read more here.
Keywords: grm; thioester; drug conjugate; antibody drug ... See more keywords
Semiaromatic Poly(thioester) from the Copolymerization of Phthalic Thioanhydride and Epoxide: Synthesis, Structure, and Properties
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecules"
DOI: 10.1021/acs.macromol.9b00073
Abstract: We report a new semiaromatic poly(thioester) obtained through the copolymerization of phthalic thioanhydride and propylene oxide. The reaction was catalyzed by a chromium-based complex in conjunction with [PPN]Cl, where PPN = bis(triphenylphosphine)iminium. The reaction temperature… read more here.
Keywords: thioester; phthalic thioanhydride; poly thioester; semiaromatic poly ... See more keywords
A Formal 1,2-Stevens Rearrangement of Thioester Ylides as a Single-Atom Molecular Editing Tool.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c04495
Abstract: A rhodium-catalyzed reaction of thioesters with diazo reagents was recognized as a powerful and unprecedented tool for single-atom molecular editing by the insertion of a single carbon atom into the C(O)─S thioester bond, thereby leading… read more here.
Keywords: formal stevens; tool; thioester; single atom ... See more keywords
Structure of the Reductase Domain of a Fungal Carboxylic Acid Reductase and Its Substrate Scope in Thioester and Aldehyde Reduction
Sign Up to like & getrecommendations! Published in 2022 at "ACS Catalysis"
DOI: 10.1021/acscatal.2c04426
Abstract: The synthesis of aldehydes from carboxylic acids has long been a challenge in chemistry. In contrast to the harsh chemically driven reduction, enzymes such as carboxylic acid reductases (CARs) are considered appealing biocatalysts for aldehyde… read more here.
Keywords: carboxylic acid; structure; domain; thioester ... See more keywords
Understanding and Circumventing the Requirement for Native Thioester Substrates for α-Oxoamine Synthase Reactions.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00365
Abstract: Many enzyme classes require thioester electrophiles such as acyl-carrier proteins and acyl-coenzyme A substrates. For in vitro applications, these substrates can render these chemical transformations impractical. To address this challenge, we have investigated the mechanism… read more here.
Keywords: oxoamine synthase; understanding circumventing; native thioester; circumventing requirement ... See more keywords
Structural basis for transthiolation intermediates in the ubiquitin pathway
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07828-9
Abstract: Transthiolation (also known as transthioesterification) reactions are used in the biosynthesis of acetyl coenzyme A, fatty acids and polyketides, and for post-translational modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins1–3. For the Ub pathway, E1… read more here.
Keywords: transthiolation intermediates; transthiolation; thioester; structural basis ... See more keywords
Investigation on thermal behaviour and optical properties of non-symmetric cholesterol-based twin liquid crystals with thioester linkages
Sign Up to like & getrecommendations! Published in 2020 at "Liquid Crystals"
DOI: 10.1080/02678292.2019.1706107
Abstract: ABSTRACT Herein, a series of novel asymmetric cholesterol-based liquid crystal compounds containing thioester linkage and an analogue containing carboxylate linking unit have been synthesised and characterised. Thermal analyses demonstrated that all desired target compounds possess… read more here.
Keywords: cholesterol based; liquid crystals; investigation thermal; thermal behaviour ... See more keywords
Post-translational activation of the C-terminus of polypeptides for the synthesis of peptide thioesters and peptide thioester surrogates
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2024.1424953
Abstract: Semisynthesis using recombinant polypeptides is a powerful approach for the synthesis of proteins having a variety of modifications. Peptide thioesters, of which the peptide C-terminus is activated by a thioester, are utilized for coupling peptide… read more here.
Keywords: peptide thioesters; thioester; activation; synthesis ... See more keywords