Elevating 4-hydroxycoumarin production through alleviating thioesterase-mediated salicoyl-CoA degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2017.05.006
Abstract: Acyl-CoAs are essential intermediates in the biosynthetic pathways of a number of industrially and pharmaceutically important molecules. When these pathways are reconstituted in a heterologous microbial host for metabolic engineering purposes, the acyl-CoAs may be… read more here.
Keywords: production; coa; coa degradation; thioesterase ... See more keywords
Structure-guided reshaping of the acyl binding pocket of 'TesA thioesterase enhances octanoic acid production in E. coli.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2020.04.010
Abstract: Medium-chain fatty acids (C6-C10) have attracted much attention recently for their unique properties compared to their long-chain counterparts, including low melting points and relatively higher carbon conversion yield. Thioesterase enzymes, which can catalyze the hydrolysis… read more here.
Keywords: chain; production; binding pocket; acyl ... See more keywords
Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.6b01139
Abstract: Polymyxins remain one of the few antibiotics available for treating antibiotic resistant bacteria. Here we describe polymyxin B thioesterase which performs the final step in polymyxin B biosynthesis. Isolated thioesterase catalyzed cyclization of an N-acetylcystamine… read more here.
Keywords: characterization unique; functional characterization; unique terminal; polymyxin ... See more keywords
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01586
Abstract: With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to… read more here.
Keywords: thioesterase; toward preclinical; activity; target ... See more keywords
Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of Fonsecaea monophora
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010485
Abstract: Dematiaceous Fonsecaea monophora is one of the major pathogens of chromoblastomycosis. It has been well established that melanization is catalyzed by the type I polyketide synthase (PKS) in F. monophora. Multidomain protein Type I PKS… read more here.
Keywords: thioesterase; fonsecaea; deletion; fonsecaea monophora ... See more keywords
Conformational Changes of Acyl Carrier Protein Switch the Chain Length Preference of Acyl-ACP Thioesterase ChFatB2
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076864
Abstract: Microbial fatty acids are synthesized by Type II fatty acid synthase and could be tailored by acyl-ACP thioesterase. With the prospects of medium-chain fatty-acid-derivative biofuels, the selectivity of thioesterase has been studied to control the… read more here.
Keywords: thioesterase; conformational changes; acyl acp; chain length ... See more keywords