Cyclodimerization of Mohangamide A by Thioesterase Domain Is Directed by Substrates.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01670
Abstract: Mohangamide A is a pseudo-dimeric nonribosomal peptide biosynthesized along with its monomer, WS9326A, and is expected to be formed by the head-to-tail cyclodimerization of linear WS9326A and another identical peptide chain with a different acyl… read more here.
Keywords: cyclodimerization; domain directed; thioesterase domain; directed substrates ... See more keywords
Diaryl Ether Formation by a Versatile Thioesterase Domain.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02813
Abstract: Oxidative coupling and oxidative rearrangement are two of the most common biosynthetic strategies to form diaryl ethers. In contrast, enzymatic diaryl ether generation that proceeds in a nonoxidative manner has not been characterized thus far.… read more here.
Keywords: versatile thioesterase; ether formation; thioesterase domain; diaryl ether ... See more keywords
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase
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DOI: 10.1038/s41467-021-27512-0
Abstract: Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural products with important applications in both medicine and agriculture. They consist of several multienzyme subunits that must interact with each other in a highly controlled… read more here.
Keywords: chain; domain; non ribosomal; type thioesterase ... See more keywords
Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase
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DOI: 10.1038/s41598-019-39778-y
Abstract: This study demonstrated that fenofibrate, a lipid-lowering drug, induced a significant time-dependent cytotoxicity of hepatoma Hep3B cells. Hep3B cells are significantly more sensitive to cell killing by fenofibrate than hepatoma HepG2, lung cancer CH27 and… read more here.
Keywords: thioesterase domain; fatty acid; domain fatty; hep3b ... See more keywords