Articles with "thioguanine" as a keyword



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Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine

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Published in 2018 at "Antiviral Research"

DOI: 10.1016/j.antiviral.2018.08.011

Abstract: Abstract Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal… read more here.

Keywords: porcine epidemic; epidemic diarrhea; like protease; papain like ... See more keywords
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Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients

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Published in 2019 at "Scandinavian Journal of Gastroenterology"

DOI: 10.1080/00365521.2019.1629006

Abstract: Abstract Background: Thioguanine is associated with liver toxicity, especially nodular regenerative hyperplasia (NRH). We assessed if liver histology alters during long-term maintenance treatment with thioguanine in patients with inflammatory bowel disease (IBD). Methods: Liver specimens… read more here.

Keywords: bowel disease; relevance; inflammatory bowel; liver ... See more keywords
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Carbon and boron nanotubes as a template material for adsorption of 6-Thioguanine chemotherapeutic: a molecular dynamics and density functional approach

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Published in 2019 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2019.1585951

Abstract: Abstract The interaction of 6-Thioguanine molecule, an antitumor drug with carbon nanotube and boron nitride nanotube (BNNT) is investigated using molecular dynamics simulations. Based on the obtained results, the strongest negative van der Waals interaction… read more here.

Keywords: density functional; molecular dynamics; bnnt; drug ... See more keywords
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Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine

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Published in 2021 at "Therapeutic Drug Monitoring"

DOI: 10.1097/ftd.0000000000000869

Abstract: Background: In inflammatory bowel disease (IBD), conventional thiopurine users cease treatment in 60% of cases within 5 years, mostly because of adverse events or nonresponse. In this study, the authors aimed to investigate the role… read more here.

Keywords: inflammatory bowel; thioguanine nucleotide; thioguanine; thiopurine methyltransferase ... See more keywords
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Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling

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Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0210869

Abstract: Dengue virus Type 2 (DENV-2) is predominant serotype causing major dengue epidemics. There are a number of studies carried out to find its effective antiviral, however to date, there is still no molecule either from… read more here.

Keywords: virtual screening; ns3 protease; ns2b ns3; denv ns2b ... See more keywords