Dynamic Basis for Auranofin Drug Recognition by Thiol-Reductases of Human Pathogens and Intermediate Coordinated Adduct Formation with Catalytic Cysteine Residues
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b00529
Abstract: In all the living systems, reactive oxygen species (ROS) metabolism provides resistance against internal and external oxidative stresses. Auranofin (AF), an FDA-approved gold [Au(I)]-conjugated drug, is known to selectively target thiol-reductases, key enzymes involved in… read more here.
Keywords: catalytic cysteines; thiol; drug; dynamic basis ... See more keywords
Thiol Reductases in Deinococcus Bacteria and Roles in Stress Tolerance
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DOI: 10.3390/antiox11030561
Abstract: Deinococcus species possess remarkable tolerance to extreme environmental conditions that generate oxidative damage to macromolecules. Among enzymes fulfilling key functions in metabolism regulation and stress responses, thiol reductases (TRs) harbour catalytic cysteines modulating the redox… read more here.
Keywords: reductases deinococcus; deinococcus bacteria; redox; deinococcus ... See more keywords