Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five‐Membered Thiolactone Ring Formation
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DOI: 10.1002/cbic.201700090
Abstract: Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural product antibiotics was first discovered over 30 years ago, the study of… read more here.
Keywords: thiolactomycin; thiolactone ring; membered thiolactone; thiolactone ... See more keywords
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins
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DOI: 10.1021/acschembio.3c00063
Abstract: In this study, an unprecedented myxobacterial siderophore termed sorangibactin was discovered by heterologous expression of a coelibactin-like nonribosomal peptide synthetase (NRPS) gene cluster from the Sorangiineae strain MSr11367 in the host Myxococcus xanthus DK1622. De… read more here.
Keywords: myxobacterial thiolactone; discovery myxobacterial; guided discovery; thiolactone ... See more keywords
Single-Step Hydrolysis and Derivatization of Homocysteine Thiolactone Using Zone Fluidics: Simultaneous Analysis of Mixtures with Homocysteine Following Separation by Fluorosurfactant-Modified Gold Nanoparticles
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DOI: 10.3390/molecules27072040
Abstract: Herein, we report a new automated flow method based on zone fluidics for the simultaneous determination of homocysteine and homocysteine thiolactone using fluorimetric detection (λext = 370 nm/λem = 480 nm). Homocysteine thiolactone is hydrolyzed… read more here.
Keywords: homocysteine thiolactone; homocysteine; thiolactone; fluidics simultaneous ... See more keywords