Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five‐Membered Thiolactone Ring Formation
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DOI: 10.1002/cbic.201700090
Abstract: Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural product antibiotics was first discovered over 30 years ago, the study of… read more here.
Keywords: thiolactomycin; thiolactone ring; membered thiolactone; thiolactone ... See more keywords