Rational design of thiolase substrate specificity for metabolic engineering applications
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DOI: 10.1002/bit.26737
Abstract: Metabolic engineering efforts require enzymes that are both highly active and specific toward the synthesis of a desired output product to be commercially feasible. The 3‐hydroxyacid (3HA) pathway, also known as the reverse β‐oxidation or… read more here.
Keywords: chain; metabolic engineering; thiolase; thiolase substrate ... See more keywords
Human Peroxisomal 3-Ketoacyl-CoA Thiolase: Tissue Expression and Metabolic Regulation : Human Peroxisomal Thiolase.
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DOI: 10.1007/978-3-030-60204-8_12
Abstract: This paper reports that the human peroxisomal 3-ketoacyl-CoA thiolase expression shows three transcripts: Tr1 (1705 bp), Tr2 (1375 bp) and Tr3 (1782 bp). Their highest expression is observed in the human liver and at a lesser extent in… read more here.
Keywords: human peroxisomal; regulation human; peroxisomal ketoacyl; expression ... See more keywords
The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
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DOI: 10.2210/pdb6hrv/pdb
Abstract: The SCP2 (sterol carrier protein 2)-thiolase (type-1) functions in the vertebrate peroxisomal, bile acid synthesis pathway, converting 24-keto-THC-CoA and CoA into choloyl-CoA and propionyl-CoA. This conversion concerns the β-oxidation chain shortening of the steroid fatty… read more here.
Keywords: thiolase type; coa; scp2 thiolase; thiolase ... See more keywords