Multifunctional adhesive polymers: Preactivated thiolated chitosan‐EDTA conjugates
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2016.10.029
Abstract: Aim The aim of this study was to synthesis preactivated thiolated chitosan‐EDTA (Ch‐EDTA‐cys‐2MNA) conjugates exhibiting in particular high mucoadhesive, cohesive and chelating properties. Methods Thiol groups were coupled with chitosan by carbodiimide reaction and further… read more here.
Keywords: edta; thiolated chitosan; chitosan edta; edta cys ... See more keywords
Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118847
Abstract: Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned… read more here.
Keywords: stat3 sirna; chitosan nanoparticles; thiolated chitosan; cancer ... See more keywords
Preparation of thiolated chitosan/silver nanowire composite hydrogels with antimicrobial activity for obstetric wound care
Sign Up to like & getrecommendations! Published in 2020 at "Materials Letters"
DOI: 10.1016/j.matlet.2020.128497
Abstract: Abstract Bacterial infection is one of the most crucial challenges toward the wound treatment. Thus, the development of highly efficient antibacterial agents with enhanced wound healing ability is of great importance. For addressing these issues,… read more here.
Keywords: tcs agnw; microscopy; antimicrobial activity; thiolated chitosan ... See more keywords
Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2021.1873370
Abstract: Abstract α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin… read more here.
Keywords: chitosan thiolated; delivery; colon targeted; thiolated chitosan ... See more keywords
Fabrication of thiolated chitosan based biodegradable nanoparticles of ticagrelor and their pharmacokinetics
Sign Up to like & getrecommendations! Published in 2022 at "Polymers and Polymer Composites"
DOI: 10.1177/09673911221108742
Abstract: The current study was aimed to design a thiolated chitosan (TC) based mucoadhesive nanoparticle (NP) formulation for enhancing the oral bioavailability of an anti-coagulant, Ticagrelor (TG). Nanoparticles (NPs) containing naturally occurring biodegradable polymers have been… read more here.
Keywords: chitosan based; particle size; thiolated chitosan; tcnps ... See more keywords
Green synthesis of hyaluronic acid coated, thiolated chitosan nanoparticles for CD44 targeted delivery and sustained release of Cisplatin in cervical carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1073004
Abstract: Cervical carcinoma is one of the most prevalent gynecological cancers throughout the world. Cisplatin is used as first line chemotherapy for treatment of cervical cancer, but it comes with plethora of side effects. The aim… read more here.
Keywords: sustained release; cd44 targeted; thiolated chitosan; release ... See more keywords
Anti-Foulant Ultrafiltration Polymer Composite Membranes Incorporated with Composite Activated Carbon/Chitosan and Activated Carbon/Thiolated Chitosan with Enhanced Hydrophilicity
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DOI: 10.3390/membranes11110827
Abstract: A rapid increase in population worldwide is giving rise to the severe problem of safe drinking water availability, necessitating the search for solutions that are effective and economical. For this purpose, membrane technology has shown… read more here.
Keywords: carbon; microscopy; thiolated chitosan; chitosan activated ... See more keywords
Thiolated Chitosan Microneedle Patch of Levosulpiride from Fabrication, Characterization to Bioavailability Enhancement Approach
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14030415
Abstract: In this study, a first attempt has been made to deliver levosulpiride transdermally through a thiolated chitosan microneedle patch (TC-MNP). Levosulpiride is slowly and weakly absorbed from the gastrointestinal tract with an oral bioavailability of… read more here.
Keywords: microneedle patch; spectroscopy; bioavailability; chitosan microneedle ... See more keywords
Pharmacokinetic Investigation to Study the In Vivo Bioavailability of Thiolated Chitosan Based Repaglinide Buccal Tablets
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DOI: 10.34172/ps.2020.62
Abstract: Background: Repaglinide (REP) is an antihyperglycemic drug having low bioavailability due to its extensive first-pass metabolism. The present study aimed to develop and pharmacokinetic investigte the thiolated chitosan (TC) based buccal tablets of REP for… read more here.
Keywords: bioavailability; rep buccal; buccal tablets; study ... See more keywords