Structure-based mechanistic insights into catalysis by tRNA thiolation enzymes.
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DOI: 10.1016/j.sbi.2020.06.002
Abstract: In all domains of life, ribonucleic acid (RNA) maturation includes post-transcriptional chemical modifications of nucleosides. Many sulfur-containing nucleosides have been identified in transfer RNAs (tRNAs), such as the derivatives of 2-thiouridine (s2U), 4-thiouridine (s4U), 2-thiocytidine… read more here.
Keywords: thiolation enzymes; structure based; based mechanistic; trna thiolation ... See more keywords