Anti-tumoural [NHC(thiolato)]Au(I) complexes derived from HIF-1α inhibitor AC1-004 target the mitochondrial redox system and show antiangiogenic effects in vivo.
Sign Up to like & getrecommendations! Published in 2023 at "ChemPlusChem"
DOI: 10.1002/cplu.202300167
Abstract: AC1-004 is a potent inhibitor of the hypoxia-inducible factor alpha (HIF-1α) pathway, essential for tumour growth, angiogenesis and metastasis. We modelled a series of gold(I) complexes on AC1-004, retaining its 5-carboalkoxybenzimidazole as an NHC ligand… read more here.
Keywords: antiangiogenic effects; gold complexes; inhibitor; ac1 004 ... See more keywords
Bis(cyclopentadienyl)nickel(II) μ-Thiolato Complexes as Proton Reduction Electrocatalysts.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b01507
Abstract: Thiolato-bridged cyclopentadienylnickel dimeric complexes have been prepared and found to be efficient and robust proton reduction electrocatalysts using acetic acid as the proton source. From cyclic voltammetry studies, moderate overpotentials of around 0.6 V and… read more here.
Keywords: reduction; bis cyclopentadienyl; proton reduction; thiolato ... See more keywords