The uses of cyclohexan-1,4-dione for the synthesis of thiophene derivatives as new anti-proliferative, prostate anticancer, c-Met and tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2087-3
Abstract: A series of heterocyclic compounds derived from the dihydrobenzo[b]thiophene derivatives were synthesized all the synthesized compounds were determined by elemental analysis, 1H NMR, 13C NMR, and MS. The newly synthesized compounds were evaluated for their… read more here.
Keywords: anti proliferative; kinase; thiophene derivatives; uses cyclohexan ... See more keywords
Effective Synthesis of Hard-To-Reach 3,4-Disubstituted Thiophene Derivatives Based on bis(2-chloropropenyl) Sulfide
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02813-2
Abstract: An efficient approach for the synthesis of hard-to-reach 3,4-disubstituted thiophene derivatives: 4,5,9,10-tetrahydrothieno[3',4;5,6]-cycloocta[1,2-c]thiophene, 1H,4H-thieno[3,4-d][1,2]dioxine, 4-(hydroxymethyl)thiophene-3-carbaldehyde, based on consecutive transformations of bis(2-chloropropenyl) sulfide has been found. Transformations were realized without isolation of the intermediate compounds. The reactivity… read more here.
Keywords: bis chloropropenyl; reach disubstituted; disubstituted thiophene; thiophene derivatives ... See more keywords
Discovery of novel thiophene derivatives as potent neuraminidase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113762
Abstract: Neuraminidase (NA) is an important target for the treatment of influenza. In this study, a new lead NA inhibitor, 4 (ZINC01121127), was discovered by pharmacophore-based virtual screening and molecular dynamic (MD) simulation. Some novel NA… read more here.
Keywords: derivatives potent; thiophene derivatives; potent neuraminidase; thiophene ... See more keywords
Reaction of CF3-ynones with methyl thioglycolate. Regioselective synthesis of 3-CF3-thiophene derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2018.07.013
Abstract: Abstract Efficient regioselective synthesis of 3-CF3-substituted thiophene derivatives was elaborated using addition of methyl thioglycolate to CF3-ynones in the presence of sodium methoxide. read more here.
Keywords: cf3 ynones; cf3; synthesis cf3; thiophene derivatives ... See more keywords
Synthesis, optical and electrochemical properties of 4,4′-bibenzo[c]thiophene derivatives
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra01189h
Abstract: We designed and synthesized unsubstituted 4,4′-bibenzo[c]thiophene 4,4′-BBT and its silyl-substituted derivatives 1,1′-Si-4,4′-BBT and 1,1′,3,3′-Si-4,4′-BBT with one or two tert-butyldimethylsilyl groups on each thiophene ring, as new π-building blocks in emitters, photosensitizers and semiconductors for organic… read more here.
Keywords: electrochemical properties; thiophene derivatives; bibenzo thiophene; fluorescence ... See more keywords
Use of Phenacyl Thiosalicylates for the Preparation of 3-Hydroxybenzo[b]thiophene Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Synlett"
DOI: 10.1055/s-0036-1591875
Abstract: In this work, we attempted to synthesize thioflavonols using rearrangement of phenacyl thiosalicylates prepared by two different approaches and subjected to cyclization under acidic conditions. Contrary to our expectations, the isolated products were identified as… read more here.
Keywords: hydroxybenzo thiophene; use phenacyl; phenacyl thiosalicylates; thiophene derivatives ... See more keywords
New approaches for the synthesis N-alkylated benzo[b]thiophene derivatives together with their Antiproliferative and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230316103419
Abstract: BACKGROUND 2-Amino thiophene derivatives are important compounds not only for their uses in many heterocyclic reactions but also due to their wide range of pharmaceutical and biological activities. OBJECTIVE The aim of this work was… read more here.
Keywords: molecular docking; cell; thiophene derivatives; cell lines ... See more keywords
Genotoxicity and anticancer effects of the aminothiophene derivatives SB-44, SB-83, and SB-200 in cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230321123950
Abstract: INTRODUCTION Thiophene derivatives have been widely studied as promising options for the treatment of solid tumors. Previous studies have shown that thiophene derivatives have antileishmanial activity and cytotoxic activity against breast, colon, and ovarian cancer… read more here.
Keywords: cancer; derivatives 200; genotoxicity anticancer; thiophene derivatives ... See more keywords
Thiophene Derivatives as Ligands for Highly Luminescent and Stable Manganese-Doped CsPbCl3 Nanocrystals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.849801
Abstract: Ligands on the surface of perovskite nanocrystals are important to stabilize the nanocrystal structure. However, the research of ligands on Mn2+ ion-doped CsPbCl3 nanocrystals (Mn: CsPbCl3 NCs), a promising candidate family for the lightning community,… read more here.
Keywords: ligands highly; derivatives ligands; doped cspbcl3; cspbcl3 ncs ... See more keywords
In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060700
Abstract: Protein kinases are seen as promising targets in controlling cell proliferation and survival in treating cancer where fused thiophene synthon was utilized in many kinase inhibitors approved by the FDA. Accordingly, this work focused on… read more here.
Keywords: cell; vegfr akt; vitro anticancer; activity ... See more keywords
The Availability of Neutral Cyan, Green, Blue and Purple Colors from Simple D–A Type Polymers with Commercially Available Thiophene Derivatives as the Donor Units
Sign Up to like & getrecommendations! Published in 2017 at "Polymers"
DOI: 10.3390/polym9120656
Abstract: In this paper, the Stille coupling reaction was used to prepare four donor–acceptor–donor (D–A–D) type monomers. For this purpose, 2,3-bis(4-methoxyphenyl) quinoxaline was used as the acceptor unit, and thiophene derivatives (3,4-ethylenedioxythiophene, or EDOT; 3-methoxythiophene, or… read more here.
Keywords: cyan green; thiophene derivatives; donor units; green blue ... See more keywords