Higher Mucosal Healing with Tumor Necrosis Factor Inhibitors in Combination with Thiopurines Compared to Methotrexate in Crohn’s Disease
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DOI: 10.1007/s10620-018-5422-8
Abstract: BackgroundThe differential impact of anti-tumor necrosis factor (anti-TNF) therapy with methotrexate versus thiopurine co-therapy on endoscopic remission remains uncertain.AimsTo compare rates of endoscopic remission based on methotrexate or thiopurine co-therapy used with anti-TNF therapy in… read more here.
Keywords: methotrexate; thiopurine; anti tnf; therapy ... See more keywords
Better Late than Never: Adding Thiopurines After Loss of Response to Infliximab Monotherapy
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DOI: 10.1007/s10620-020-06681-w
Abstract: Since infliximab (IFX), a monoclonal antibody that specifically targets tumor necrosis factor (TNF), is efficacious and safe in the treatment for Crohn’s disease (CD), IFX therapy has become a popular choice for the induction and… read more here.
Keywords: disease; lor; thiopurine; therapy ... See more keywords
A well-tolerated and rapidly acting thiopurine for IBD?
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DOI: 10.1016/j.drudis.2018.09.001
Abstract: Thiopurine drugs continue to be a cornerstone of inflammatory bowel disease (IBD) treatment. Thiopurines are economical compared with many newer medical treatments for IBD, other chronic inflammatory diseases and leukaemia, although they are not without… read more here.
Keywords: rapidly acting; thiopurine; tolerated rapidly; ibd ... See more keywords
6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells
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DOI: 10.1021/acs.jmedchem.2c01010
Abstract: Thiopurines are in widespread clinical use for the treatment of immunological disorders and certain cancers. However, treatment failure due to resistance or adverse drug reactions are common, asking for new therapeutic strategies. We investigated the… read more here.
Keywords: monophosphate prodrugs; 6sgmp prodrugs; prodrugs display; thioguanosine monophosphate ... See more keywords
Predictive algorithm for thiopurine-induced hepatotoxicity in IBD patients.
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DOI: 10.1093/ecco-jcc/jjab232.721
Abstract: BACKGROUND Approximately 25% of patients with inflammatory bowel disease (IBD) discontinue azathioprine (AZA) or mercaptopurine (MP) therapy within 3 months of treatment initiation due to adverse drug reactions. Of these side-effects, about half are due… read more here.
Keywords: thiopurine induced; hepatotoxicity; induced hepatotoxicity; algorithm thiopurine ... See more keywords
Distribution of Genetic Polymorphisms of Genes Implicated in Thiopurine Drugs Metabolism
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DOI: 10.1097/ftd.0000000000000548
Abstract: Abstract: Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation in the expression of TPMT and ITPA is caused by single nucleotide polymorphisms of… read more here.
Keywords: itpa; polymorphisms genes; thiopurine; tpmt ... See more keywords
Azathioprine-induced vanishing bile duct syndrome: the value of early thiopurine metabolism assessment.
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DOI: 10.1111/bcp.15797
Abstract: About 15 to 28% of treated patients with thiopurines experienced adverse drug reactions, such as hematological and hepatic toxicities. A part of them is related to the polymorphic activity of the thiopurine S-methyltransferase (TPMT), the… read more here.
Keywords: duct; metabolism; azathioprine; blood ... See more keywords
NUDT15: A major determinant of thiopurine sensitivity in Asians
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DOI: 10.1111/ped.14558
Abstract: Pharmacogenetics is the study focusing on genetic variations that affect sensitivity to specific medications. Recent advances in this field have enabled us to provide individualized medicine based on genetic characteristics, and genomic variants conferring thiopurine… read more here.
Keywords: medicine; maintenance therapy; frequency nudt15; sensitivity ... See more keywords
Impact of thiopurine dose in anti-tumor necrosis factor combination therapy on outcomes in inflammatory bowel disease
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DOI: 10.20524/aog.2022.0766
Abstract: Background Combination therapy with thiopurines and anti-tumor necrosis factor (TNF) is superior to monotherapy in Crohn’s disease (CD) and ulcerative colitis (UC). The optimal dose of thiopurines in combination therapy remains unclear. We investigated the… read more here.
Keywords: thiopurine dose; thiopurine; combination therapy;
Evaluation of prescriber responses to pharmacogenomics clinical decision support for thiopurine S‐methyltransferase testing
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DOI: 10.2146/ajhp170280
Abstract: Purpose Results of a study of prescribers’ responses to a pharmacogenomics‐based clinical decision support (CDS) alert designed to prompt thiopurine S‐methyltransferase (TPMT) status testing are reported. Methods A single‐center, retrospective, chart review–based study was conducted… read more here.
Keywords: responses pharmacogenomics; prescriber; decision support; thiopurine ... See more keywords
MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia
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DOI: 10.3324/haematol.2017.176362
Abstract: Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in MSH6, a crucial part of DNA mismatch repair, are frequently… read more here.
Keywords: msh6; lymphoblastic leukemia; thiopurine; resistance ... See more keywords