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Published in 2018 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000548
Abstract: Abstract: Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation in the expression of TPMT and ITPA is caused by single nucleotide polymorphisms of…
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Keywords:
itpa;
polymorphisms genes;
thiopurine;
tpmt ... See more keywords
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Published in 2022 at "Toxics"
DOI: 10.3390/toxics10040151
Abstract: The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications. Since then, they have been used routinely to…
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Keywords:
cytotoxicity thiopurine;
inflammatory bowel;
thiopurine drugs;
disease ... See more keywords