Distribution of Genetic Polymorphisms of Genes Implicated in Thiopurine Drugs Metabolism
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DOI: 10.1097/ftd.0000000000000548
Abstract: Abstract: Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation in the expression of TPMT and ITPA is caused by single nucleotide polymorphisms of… read more here.
Keywords: itpa; polymorphisms genes; thiopurine; tpmt ... See more keywords
Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease
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DOI: 10.3390/toxics10040151
Abstract: The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications. Since then, they have been used routinely to… read more here.
Keywords: cytotoxicity thiopurine; inflammatory bowel; thiopurine drugs; disease ... See more keywords