Predictive algorithm for thiopurine-induced hepatotoxicity in IBD patients.
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DOI: 10.1093/ecco-jcc/jjab232.721
Abstract: BACKGROUND Approximately 25% of patients with inflammatory bowel disease (IBD) discontinue azathioprine (AZA) or mercaptopurine (MP) therapy within 3 months of treatment initiation due to adverse drug reactions. Of these side-effects, about half are due… read more here.
Keywords: thiopurine induced; hepatotoxicity; induced hepatotoxicity; algorithm thiopurine ... See more keywords
NUDT15 polymorphism and severe azathioprine‐induced myelosuppression in a Chinese man with pemphigus vulgaris
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.15840
Abstract: DEAR EDITOR, Pemphigus vulgaris (PV) is a life-threatening autoimmune mucocutaneous disease with formidable treatment challenges. Since the first report of successful treatment of PV in 1969 with azathioprine (AZA), which was originally used to treat… read more here.
Keywords: pemphigus vulgaris; dermatology; myelosuppression; thiopurine induced ... See more keywords
Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT
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DOI: 10.1186/s12967-020-02416-7
Abstract: NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients with both wild-type (WT) NUDT15 and TPMT still suffer… read more here.
Keywords: variant; thiopurine induced; nudt15 tpmt; tpmt ... See more keywords
Associations between the NUDT15 R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis
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DOI: 10.2147/ott.s177007
Abstract: Background and aim Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced… read more here.
Keywords: r139c polymorphism; thiopurine induced; nudt15 r139c; model ... See more keywords
Nudix Hydroxylase 15 Mutations Strongly Predict Thiopurine-Induced Leukopenia Across Different Asian Ethnicities: Implications for Screening in a Diverse Population
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DOI: 10.3389/fmed.2022.880937
Abstract: Background and Aims Thiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with monoethnic… read more here.
Keywords: induced leukopenia; thiopurine induced; nudix hydroxylase; leukopenia across ... See more keywords