Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease
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DOI: 10.1097/cm9.0000000000000756
Abstract: To the Editor: Rheumatic diseases are disorders characterized by joint inflammation, but other organs are also affected. Rheumatic diseases are common in China, and the clinical application of azathioprine (AZA), a purine analog immunosuppressant, for… read more here.
Keywords: thiopurine methyltransferase; methyltransferase nudt15; polymorphisms azathioprine; association thiopurine ... See more keywords
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine
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DOI: 10.1097/ftd.0000000000000869
Abstract: Background: In inflammatory bowel disease (IBD), conventional thiopurine users cease treatment in 60% of cases within 5 years, mostly because of adverse events or nonresponse. In this study, the authors aimed to investigate the role… read more here.
Keywords: inflammatory bowel; thioguanine nucleotide; thioguanine; thiopurine methyltransferase ... See more keywords
Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune Diseases
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DOI: 10.3390/jpm12091399
Abstract: Thiopurine methyltransferase (TPMT) is the rate-limiting enzyme in Azathioprine (AZA) metabolization. Although studies have discussed the association between the TPMT polymorphisms and myelosuppression, the data about the relationship between TPMT genotypes and hepatoxicity in Asian… read more here.
Keywords: thiopurine methyltransferase; non; hepatotoxicity; tpmt ... See more keywords