Thiopurine Therapy in Patients With Inflammatory Bowel Disease: A Focus on Metabolism and Pharmacogenetics
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05720-5
Abstract: Thiopurines have been widely used for the maintenance of remission or steroid sparing in patients with inflammatory bowel disease. However, potential drug-related adverse events frequently interfere with their use. Indeed, drug withdrawals associated with adverse… read more here.
Keywords: inflammatory bowel; bowel disease; thiopurine therapy; patients inflammatory ... See more keywords
TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.837164
Abstract: Variants in thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) are associated with an accumulation of cytotoxic metabolites leading to increased risk of drug-related toxicity with standard doses of thiopurine drugs. We established TPMT and… read more here.
Keywords: testing thiopurine; gene; thiopurine therapy; tpmt nudt15 ... See more keywords