Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1103-4
Abstract: BackgroundThe redox regulatory protein, thioredoxin-interacting protein (TXNIP), has been confirmed as an important tumor suppressor gene in various types of human cancers. In previous studies, we found that overexpression of tumor suppressor gene RIZ1 in… read more here.
Keywords: recurrence; expression txnip; thioredoxin interacting; expression ... See more keywords
Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0917-z
Abstract: Neurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer’s disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease… read more here.
Keywords: protein; neurodegenerative diseases; pathology; thioredoxin interacting ... See more keywords
Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.08.114
Abstract: Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex.… read more here.
Keywords: thioredoxin interacting; thioredoxin; expression; interacting protein ... See more keywords
Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Investigation"
DOI: 10.1038/s41374-018-0078-8
Abstract: Thioredoxin-interacting protein (TXNIP) is associated with inflammation, tubulointerstitial fibrosis, and oxidative stress in diabetic kidney disease, yet the potential role of TXNIP in nondiabetic renal injury is not well known. This study aimed to investigate… read more here.
Keywords: unilateral ureteral; fibrosis; inflammation; thioredoxin interacting ... See more keywords
Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s232221
Abstract: Abstract Diabetes mellitus (DM) is a common metabolic disorder which is characterized by a persistent increment of blood glucose. Globally, DM affects millions of people and the prevalence is increasing alarmingly. The critical step in… read more here.
Keywords: thioredoxin interacting; txnip; protein novel; diabetes mellitus ... See more keywords
Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.955128
Abstract: Target identification is essential for developing novel therapeutic strategies in diseases. Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2, is a member of the α-arrestin protein family and is regulated by several cellular stress factors.… read more here.
Keywords: bone metabolism; thioredoxin interacting; bone; interacting protein ... See more keywords
An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1153805
Abstract: Thioredoxin-interacting protein (TXNIP) was first isolated from Vitamin D3-exposed HL60 cells. TXNIP is the main redox-regulating factor in various organs and tissues. We begin with an overview of the TXNIP gene and protein information, followed… read more here.
Keywords: txnip; thioredoxin interacting; interacting protein; kidney disease ... See more keywords