Exploring Thioredoxin‐Interacting Protein (TXNIP) as a Therapeutic Target for Cardiovascular Diseases
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70082
Abstract: Cardiovascular diseases (CVDs) are the primary causes of death globally. Risk factors such as aging, poor lifestyle, and genetics significantly influence how these diseases progress, with oxidative stress being an important factor in their pathogenesis.… read more here.
Keywords: therapeutic target; txnip; cardiovascular diseases; interacting protein ... See more keywords
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1103-4
Abstract: BackgroundThe redox regulatory protein, thioredoxin-interacting protein (TXNIP), has been confirmed as an important tumor suppressor gene in various types of human cancers. In previous studies, we found that overexpression of tumor suppressor gene RIZ1 in… read more here.
Keywords: recurrence; expression txnip; thioredoxin interacting; expression ... See more keywords
Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0917-z
Abstract: Neurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer’s disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease… read more here.
Keywords: protein; neurodegenerative diseases; pathology; thioredoxin interacting ... See more keywords
Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.08.114
Abstract: Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex.… read more here.
Keywords: thioredoxin interacting; thioredoxin; expression; interacting protein ... See more keywords
Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Investigation"
DOI: 10.1038/s41374-018-0078-8
Abstract: Thioredoxin-interacting protein (TXNIP) is associated with inflammation, tubulointerstitial fibrosis, and oxidative stress in diabetic kidney disease, yet the potential role of TXNIP in nondiabetic renal injury is not well known. This study aimed to investigate… read more here.
Keywords: unilateral ureteral; fibrosis; inflammation; thioredoxin interacting ... See more keywords
Correlations of Thioredoxin and Thioredoxin Interacting Protein with Type 2 Diabetes Mellitus Complicated with Diabetic Retinopathy
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DOI: 10.1080/02713683.2025.2487069
Abstract: Abstract Purpose To investigate the relationship between Thioredoxin (Trx), Thioredoxin interacting protein (Txnip), and the severity of diabetic retinopathy (DR). Methods The study involved a total of 101 eyes, comprising of 31 healthy controls, 24… read more here.
Keywords: correlation; diabetic retinopathy; interacting protein; thioredoxin interacting ... See more keywords
Abstract LB323: Thioredoxin interacting protein (TXNIP), a regulator of oxidative stress, mediates the RAPGEF3/4 (EPAC1/2) signaling required for melanoma progression
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb323
Abstract: Exchange proteins directly activated by cyclic AMP (EPACs) are RAP guanine nucleotide exchange factors (RAPGEFs). We showed that EPAC signaling is required for the survival and growth of human primary, but not metastatic, melanoma cell… read more here.
Keywords: mice; signaling required; melanoma; interacting protein ... See more keywords
Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s232221
Abstract: Abstract Diabetes mellitus (DM) is a common metabolic disorder which is characterized by a persistent increment of blood glucose. Globally, DM affects millions of people and the prevalence is increasing alarmingly. The critical step in… read more here.
Keywords: thioredoxin interacting; txnip; protein novel; diabetes mellitus ... See more keywords
Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.955128
Abstract: Target identification is essential for developing novel therapeutic strategies in diseases. Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2, is a member of the α-arrestin protein family and is regulated by several cellular stress factors.… read more here.
Keywords: bone metabolism; thioredoxin interacting; bone; interacting protein ... See more keywords
An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1153805
Abstract: Thioredoxin-interacting protein (TXNIP) was first isolated from Vitamin D3-exposed HL60 cells. TXNIP is the main redox-regulating factor in various organs and tissues. We begin with an overview of the TXNIP gene and protein information, followed… read more here.
Keywords: txnip; thioredoxin interacting; interacting protein; kidney disease ... See more keywords
Pycnogenol-Assisted Alleviation of Titanium Dioxide Nanoparticle-Induced Lung Inflammation via Thioredoxin-Interacting Protein Downregulation
Sign Up to like & getrecommendations! Published in 2024 at "Antioxidants"
DOI: 10.3390/antiox13080972
Abstract: Titanium dioxide nanoparticles (TiO2NPs) are used in products that are applied to the human body, such as cosmetics and food, but their biocompatibility remains controversial. Pycnogenol (PYC), a natural extract of pine bark, exerts anti-inflammatory… read more here.
Keywords: titanium dioxide; induced lung; interacting protein; thioredoxin interacting ... See more keywords